West Virginia vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 5 [2026]

Using trusted machine learning and data analysis, we have re-simulated the result of West Virginia vs. Iowa State, forming part of our college football predictions coverage.

Our famous predictive model currently gives Iowa State a 57.8% chance of defeating West Virginia. Our predicted final score has Iowa State winning 27-25. According to our model, West Virginia (+3.5) has a 54.8% chance of covering the spread, while the 53.5-point over/under has a 50.4% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: West Virginia +3.5 (-115) / Iowa State -3.5 (+101)
• Moneyline: West Virginia +135, Iowa State -152
• Total: Over/Under 53.5 (-105/-107)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: West Virginia +3.5 @ -115 via bet365
• Moneyline: West Virginia @ +135 via bet365
• Total: Under 53.5 @ -107 via BetRivers

According to our college football best bets, the top play to make on this game is West Virginia +3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Iowa State and West Virginia at Jack Trice Stadium is scheduled to start at 12:00 PM ET.

• Who: West Virginia vs. Iowa State
• Date: Saturday, October 3, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Jack Trice Stadium

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Conclusion

We predict Iowa State, with a 57.8% win probability, will likely beat West Virginia in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.