Sep 19, 2026
Princeton vs. Bryant prediction favors Princeton to win in college football Week 3 [2026]
Read Article Southern Illinois vs. Illinois prediction: Why Illinois is favored to win in college football Week 3 [2026]
Updated: | First published:
Add Dimers on Google 
Written by Mac Douglass, Senior Editor
Dimers' simulation model projects a 99.2% win probability for Illinois at Gies Memorial Stadium (Champaign.
Illinois will square off with Southern Illinois in Week 3 college football action at Gies Memorial Stadium on Saturday, with kickoff at 2:00 PM ET.
Dimers' proven college football model projects Illinois as the most likely winner in this Southern Illinois vs. Illinois prediction.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Southern Illinois vs. Illinois prediction and odds
Using powerful machine learning and data analysis, we have re-simulated the result of Southern Illinois vs. Illinois, forming part of our college football predictions coverage.
Plus, check out the latest details on the current offer from Polymarket.
Our famous predictive model gives Illinois a 99.2% chance of defeating Southern Illinois. Our predicted final score has Illinois winning 46-8. According to our model, Southern Illinois (+39.5) has a 53.4% chance of covering the spread, while the 55.5-point over/under has a 54.0% chance of staying under.
Latest betting odds
We have sourced the best college football odds in America for this game, which are listed here:
- Spread: Southern Illinois +39.5 (-110) / Illinois -39.5 (-110)
- Moneyline: Southern Illinois , Illinois
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Moneyline: Under @ -110 via Bet365
According to our best college football bets, the top play to make on this game is under 55.5 points.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & kickoff details
Saturday's college football game between Illinois and Southern Illinois at Gies Memorial Stadium is scheduled to begin at 2:00 PM ET.
- Who: Southern Illinois vs. Illinois
- Date: Saturday, September 19, 2026
- Time: 2:00 PM ET/11:00AM PT
- Venue: Gies Memorial Stadium
College football Week 3 promos
Make the most of Dimers' Southern Illinois vs. Illinois predictions by exploring the Underdog Fantasy offer below:
Conclusion
We predict Illinois, with a 99.2% win probability, will likely beat Southern Illinois in Saturday's college football matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
Every Bet, Every Game, Every Day Every plan unlocks every model, tool and insight, only the billing term changes.
MOST FLEXIBLE
Monthly billed monthly
$29.99
Month to month Pay as you go RECOMMENDED
6 Months one payment
$119.99 $149.99
6 months $20 per month Save $30.00 · 20% LIMITED TIME OFFER BEST VALUE
Annual first year
$169.99 $199.99
12 months $14.17 per month Save $30.00 · 15% LIMITED TIME OFFER Every plan includes
Full site access
iOS & Android app
AI bet assistant
Unlimited picks & predictions
Unlimited best bets & props
Unlimited player projections
Private Discord community
Cancel or pause anytime
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure
