Louisiana-Lafayette vs. Southern California prediction favors Southern California to win in college football Week 2 [2026]

Using powerful machine learning and statistical analysis, we have re-simulated the result of Louisiana-Lafayette vs. Southern California, forming part of our college football predictions coverage.

Our famous predictive model gives Southern California a 98.1% chance of defeating Louisiana-Lafayette. Our predicted final score has Southern California winning 44-14. According to our model, Louisiana-Lafayette (+31) has a 52.4% chance of covering the spread, while the over/under total of 59.5 points has a 52.0% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Louisiana-Lafayette +31 (-107) / Southern California -31 (-109)
• Moneyline: Louisiana-Lafayette +3000, Southern California -5000
• Total: Over/Under 59.5 (-105/-109)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Louisiana-Lafayette +31 @ -107 via BetRivers
• Moneyline: Southern California @ -5000 via DraftKings
• Total: Under 59.5 @ -109 via Caesars

According to our college football best bets, the top play to make on this game is Louisiana-Lafayette +31 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Southern California and Louisiana-Lafayette at Los Angeles Memorial Coliseum is scheduled to start at 11:00 PM ET.

• Who: Louisiana-Lafayette vs. Southern California
• Date: Saturday, September 12, 2026
• Time: 11:00 PM ET/8:00PM PT
• Venue: Los Angeles Memorial Coliseum

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Conclusion

We predict Southern California, with a 98.1% win probability, will likely beat Louisiana-Lafayette in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.