UConn vs. Southern Miss prediction favors Connecticut to win in college football Week 3 [2026]

Using innovative machine learning and data analysis, we have re-simulated the outcome of UConn vs. Southern Miss, forming part of our college football predictions coverage.

Our independent predictive model gives Connecticut a 59.1% chance of beating Southern Miss. Our predicted final score has Connecticut winning 28-25. According to our model, Southern Miss (+3.5) has a 54.1% chance of covering the spread, while the over/under total of 54.5 points has a 50.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: UConn -3.5 (+100) / Southern Miss +3.5 (-120)
• Moneyline: UConn -159, Southern Miss +140
• Total: Over/Under 54.5 (-110/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Miss +3.5 @ -120 via bet365
• Moneyline: Southern Miss @ +140 via bet365
• Total: Over 54.5 @ -110 via Caesars

According to our college football best bets, the top play to make on this game is Southern Miss +3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Southern Miss and UConn at M.M. Roberts Stadium is scheduled to commence at 7:00 PM ET.

• Who: Connecticut vs. Southern Miss
• Date: Saturday, September 19, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: M.M. Roberts Stadium

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Conclusion

We predict Connecticut, with a 59.1% win probability, will likely beat Southern Miss in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.