Notre Dame vs. Purdue prediction: Why Notre Dame is favored to win in college football Week 4 [2026]

Using powerful machine learning and data analysis, we have re-simulated the result of Notre Dame vs. Purdue, forming part of our college football predictions coverage.

Our independent predictive model gives Notre Dame a 97.6% chance of defeating Purdue. Our predicted final score has Notre Dame winning 42-15. According to our model, Purdue (+27.5) has a 51.4% chance of covering the spread, while the 57.5-point over/under has a 50.6% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Notre Dame -27.5 (-109) / Purdue +27.5 (-104)
• Moneyline: Notre Dame -4500, Purdue +2000
• Total: Over/Under 57.5 (-105/-109)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Purdue +27.5 @ -104 via FanDuel
• Moneyline: Notre Dame @ -4500 via DraftKings
• Total: Over 57.5 @ -105 via bet365

According to our best college football bets, the top play to make on this game is Purdue +27.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Purdue and Notre Dame at Ross-Ade Stadium is scheduled to commence at 2:00 PM ET.

• Who: Notre Dame vs. Purdue
• Date: Saturday, September 26, 2026
• Time: 2:00 PM ET/11:00AM PT
• Venue: Ross-Ade Stadium

College football Week 4 promos

Make the most of Dimers' Notre Dame vs. Purdue predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Notre Dame, with a 97.6% win probability, will likely beat Purdue in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.