Northwestern vs. Ohio State prediction favors Ohio State to win in college football Week 11 [2026]

Using powerful machine learning and statistical analysis, we have re-simulated the result of Northwestern vs. Ohio State, forming part of our college football predictions coverage.

Our leading predictive model gives Ohio State an 84.8% chance of defeating Northwestern. Our predicted final score has Ohio State winning 30-16. According to our model, Northwestern (+14.5) has a 50.9% chance of covering the spread, while the 45.5-point over/under has a 54.7% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Northwestern +14.5 (-115) / Ohio State -14.5 (+111)
• Moneyline: Northwestern +471, Ohio State -506
• Total: Over/Under 45.5 (+102/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Ohio State -14.5 @ 48¢ via Novig
• Moneyline: Ohio State @ 84¢ via Novig
• Total: Over 45.5 @ 50¢ via Novig

According to our college football best bets, the top play to make on this game is Over 45.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Ohio State and Northwestern at Ohio Stadium is scheduled to begin at 12:00 PM ET.

• Who: Northwestern vs. Ohio State
• Date: Saturday, November 14, 2026
• Time: 12:00 PM ET/9:00 AM PT
• Venue: Ohio Stadium

College football Week 11 promos

Make the most of Dimers' Northwestern vs. Ohio State predictions by exploring the Bet365 Sportsbook offer below:

In Texas or Oklahoma? Check out this exclusive offer where you can secure $25 in Predictions Dollars as soon as either team scores in today's Sooners-Longhorns clash.

Conclusion

We predict Ohio State, with an 84.8% win probability, will likely beat Northwestern in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.