Lafayette vs. William & Mary prediction: Why Lafayette is favored to win in college football Week 10 [2026]

Using trusted machine learning and statistical analysis, we have re-simulated the outcome of Lafayette vs. William & Mary, forming part of our college football predictions coverage.

Our leading predictive model currently gives Lafayette a 58.7% chance of defeating William & Mary. Our predicted final score has Lafayette winning 27-24. According to our model, Lafayette (-1.5) has a 53.4% chance of covering the spread, while the 51.5-point over/under has a 52.8% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Lafayette -1.5 (-167) / William & Mary +1.5 (+122)
• Moneyline: Lafayette -135, William & Mary +127
• Total: Over/Under 51.5 (-108/+100)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: William & Mary +1.5 @ 45¢ via Novig
• Moneyline: Lafayette @ 58¢ via Novig
• Total: Over 51.5 @ 52¢ via Novig

According to our best college football bets, the top play to make on this game is William & Mary +1.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between William & Mary and Lafayette at Walter J. Zable Stadium at Cary Field is scheduled to commence at 1:00 PM ET.

• Who: Lafayette vs. William & Mary
• Date: Saturday, November 7, 2026
• Time: 1:00 PM ET/10:00 AM PT
• Venue: Walter J. Zable Stadium at Cary Field

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Conclusion

We predict Lafayette, with a 58.7% win probability, will likely beat William & Mary in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.