Iowa vs. Northwestern prediction favors Iowa to win in college football Week 10 [2026]

Using innovative machine learning and statistical analysis, we have re-simulated the outcome of Iowa vs. Northwestern, forming part of our college football predictions coverage.

Our leading predictive model currently gives Iowa a 56.2% chance of beating Northwestern. Our predicted final score has Iowa winning 24-21. According to our model, Iowa (+2.5) has a 61.9% chance of covering the spread, while the over/under total of 42.5 points has a 57.9% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Iowa +2.5 (-163) / Northwestern -2.5 (+150)
• Moneyline: Iowa -130, Northwestern +127
• Total: Over/Under 42.5 (-108/+100)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Iowa +2.5 @ 62¢ via Novig
• Moneyline: Northwestern @ 44¢ via Novig
• Total: Over 42.5 @ 52¢ via Novig

According to our college football best bets, the top play to make on this game is Over 42.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Northwestern and Iowa at Ryan Field is scheduled to commence at 7:30 PM ET.

• Who: Iowa vs. Northwestern
• Date: Saturday, November 7, 2026
• Time: 7:30 PM ET/4:30 PM PT
• Venue: Ryan Field

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Conclusion

We predict Iowa, with a 56.2% win probability, will likely beat Northwestern in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.