Florida vs. Missouri prediction: Why Florida is favored to win in college football Week 5 [2026]

Using innovative machine learning and statistical analysis, we have re-simulated the result of Florida vs. Missouri, forming part of our college football predictions coverage.

Our famous predictive model gives Florida a 69.2% chance of defeating Missouri. Our predicted final score has Florida winning 31-25. According to our model, Florida (-5.5) has a 53.0% chance of covering the spread, while the over/under total of 57.5 points has a 51.1% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Florida -5.5 (-107) / Missouri +5.5 (-110)
• Moneyline: Florida -213, Missouri +180
• Total: Over/Under 57.5 (-110/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Florida -5.5 @ -107 via Caesars
• Moneyline: Florida @ -213 via Caesars
• Total: Under 57.5 @ -105 via bet365

According to our college football best bets, the top play to make on this game is Florida -5.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Missouri and Florida at Memorial Stadium/Faurot Field is scheduled to commence at 3:30 PM ET.

• Who: Florida vs. Missouri
• Date: Saturday, October 3, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Memorial Stadium/Faurot Field

College football Week 5 promos

Make the most of Dimers' Florida vs. Missouri predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Florida, with a 69.2% win probability, will likely beat Missouri in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.