Eastern Illinois vs. Illinois State prediction: Why Illinois State is favored to win in college football Week 3 [2026]

Using trusted machine learning and data, we have re-simulated the result of Eastern Illinois vs. Illinois State, forming part of our college football predictions coverage.

Our famous predictive model gives Illinois State a 96.7% chance of defeating Eastern Illinois. Our predicted final score has Illinois State winning 41-12. According to our model, Eastern Illinois (+29.5) has a 51.2% chance of covering the spread, while the 53.5-point over/under has a 50.9% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Eastern Illinois +29.5 (-110) / Illinois State -29.5 (-110)
• Moneyline: Eastern Illinois , Illinois State

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Over @ -112 via DraftKings

According to our college football best bets, the top play to make on this game is Eastern Illinois +29.5.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Illinois State and Eastern Illinois at Hancock Stadium is scheduled to commence at 3:00 PM ET.

• Who: Eastern Illinois vs. Illinois State
• Date: Saturday, September 19, 2026
• Time: 3:00 PM ET/12:00PM PT
• Venue: Hancock Stadium

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Conclusion

We predict Illinois State, with a 96.7% win probability, will likely beat Eastern Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.