South Florida vs. DePaul prediction, odds, pick for Nov. 5, 2026

DePaul is favored to beat South Florida at Wintrust Arena on Thursday (8:30 PM ET), according to Dimers' men's college basketball model.

Our South Florida vs. DePaul prediction gives DePaul a 72.6% chance of winning, while the latest odds suggest there's betting value on the under 149.5 points.

South Florida vs. DePaul key predictions

• Predicted score: DePaul 76-70 South Florida
• DePaul win probability: 72.6%
• South Florida win probability: 27.4%
• South Florida +6.5 spread: 50.6% cover probability
• Under 149.5 points: 53.9% probability

Our men's college basketball predictions project each team's final score using offensive and defensive efficiency, recent performance, long-term trends, and matchup-specific factors.

We calculate win, spread, and total probabilities based on these projections and historical CBB scoring patterns, then compare them with the latest odds to find betting value.

South Florida vs. DePaul odds

Here are the best available odds across the moneyline, spread, and total points markets we track.

• South Florida moneyline: +235 (BetRivers)
• DePaul moneyline: -275 (BetMGM)
• South Florida +6.5: -108 (DraftKings)
• DePaul -6.5: -105 (BetMGM)
• Over 149.5 points: -112 (DraftKings)
• Under 149.5 points: -105 (FanDuel)

Odds are subject to change and may vary by location.

South Florida vs. DePaul pick: Under 149.5 (-105)

Our model makes DePaul the likelier winner, but our best value bet is the under 149.5 total points at -105 on FanDuel.

Those odds give the under an implied probability of 51.2%, while our model puts it at 53.9%.

That's a 2.7% edge, the largest across the moneyline, spread, and total points markets for this game.

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South Florida vs. DePaul game details

• Matchup: South Florida Bulls vs. DePaul Blue Demons
• Date: Thursday, November 5, 2026
• Time: 8:30 PM ET
• Venue: Wintrust Arena

About this prediction

This preview uses predictions from our men's college basketball models, presented through a template written by our editorial team. Matchup details fill in automatically.

Predictions are estimates, not guarantees, and can change as new information comes in, such as injury news or lineup changes. Learn how our predictions work.

Dimers encourages responsible gambling.