South Florida vs. DePaul Prediction, Picks & Odds

Dimers' South Florida vs. DePaul prediction for Thursday, November 5, 2026. Win probabilities, projected final score, current odds, and picks from our college basketball machine learning model.
MEN'S CBB
CBB sport icon
MEN'S CBB
South Florida USF
Predicted score
71
:
77
Wintrust Arena
DePaul DEP
Wintrust Arena
Pre-Game Probabilities Last updated:

Spread

South Florida +6.5
Spread
  • South Florida
    50.6%
    BetRiversBetRivers
  • DePaul
    49.4%
    DraftKingsDraftKings

South Florida vs. DePaul prediction & analysis

Game overview: Men's college basketball Thursday

  • Teams: South Florida vs. DePaul
  • Date: Thursday, November 5, 2026
  • Tip-off: 8:30PM ET
  • Venue: Wintrust Arena

Current betting odds

  • Spread: South Florida (+6.5, -110), DePaul (-6.5, -108)
  • Total (Over/Under): 150.5 points (-108/-105)
  • Moneyline: South Florida +240, DePaul -280

Dimers’ win probabilities

  • South Florida: 27.4%
  • DePaul: 72.6%

Our college basketball win probabilities come from a machine learning model that assesses each team's offensive and defensive performance, along with factors such as recent form, player availability, home-court advantage, and matchup dynamics.

The model uses these projections to forecast probabilities for the moneyline, spread, total points, and final score.

Projected Final Score

Our model projects the final score for this college basketball matchup as South Florida 70 and DePaul 77.

This is a margin of 7 points against a spread of 6.5, and a projected total of 147 points against a market line of 150.5.

A projected score is the middle of a range, not a forecast of the exact result. Use it to see how the game is likely to play out and how each side projects against the spread.

Our Prediction: Who Wins?

After extensive simulations, our model gives South Florida a win probability of 27.4%, while DePaul has a win probability of 72.6%.

Summary

According to our analysis, DePaul is more likely to beat South Florida in the men's college basketball game at Wintrust Arena on Thursday.

Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our South Florida vs. DePaul predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert men's college basketball predictions and the best men's college basketball bets today, while our in-depth analysis includes men's college basketball props, men's college basketball futures, men's college basketball odds, and the latest men's college basketball news.