Cardinals vs. Saints: NFL Week 16 Prediction, Picks & Odds
Spread
- Cardinals
- Saints
Cardinals vs. Saints: Detailed Breakdown
Matchup overview: NFL Week 16
- Teams: Arizona Cardinals vs. New Orleans Saints
- Date: Sunday, December 27, 2026
- Time: 1:00PM ET
- Venue: Caesars Superdome
Current betting odds
- Spread: Cardinals (+5.5, -115), Saints (-5.5, -115)
- Moneyline: Cardinals +200, Saints -250
- Total (Over/Under): 43.5 points (-115/-115)
Dimers’ win probabilities
- Cardinals: 32.1%
- Saints: 67.9%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Cardinals 19-25 Saints.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models
Our Prediction: Who Wins?
The numbers give the Cardinals a win probability of 32.1%, while the Saints have a win probability of 67.9%.
Summary
The Cardinals face off against the Saints in the NFL at Caesars Superdome on Sunday, December 27, 2026.
Our Cardinals vs. Saints predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.
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