Giants vs. Lions: NFL Week 16 Prediction, Picks & Odds
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- Giants
- Lions
Giants vs. Lions: Detailed Breakdown
Matchup overview: NFL Week 16
- Teams: New York Giants vs. Detroit Lions
- Date: Monday, December 28, 2026
- Time: 8:15PM ET
- Venue: Ford Field
Current betting odds
- Spread: Giants (+6.5, -115), Lions (-6.5, -115)
- Moneyline: Giants +210, Lions -275
- Total (Over/Under): 49.5 points (-115/-115)
Dimers’ win probabilities
- Giants: 32.3%
- Lions: 67.7%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Giants 22-27 Lions.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models
Our Prediction: Who Wins?
The numbers give the Giants a win probability of 32.3%, while the Lions have a win probability of 67.7%.
Summary
The Giants face off against the Lions in the NFL at Ford Field on Monday, December 28, 2026.
Our Giants vs. Lions predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.