Seahawks vs. 49ers: NFL Week 12 Prediction, Picks & Odds

Dimers' Seahawks vs. 49ers prediction for Sunday, November 29, 2026. Win probabilities, projected final score, current odds, and picks from our NFL machine learning models.
NFL
NFL sport icon
NFL
Seahawks
Predicted score
23
:
24
Levi's Stadium
49ers
Levi's Stadium
Pre-Game Probabilities Last Update:

Spread

49ers -1.5
Spread
  • Seahawks
    48.6%
    CaesarsCaesars
  • 49ers
    51.4%
    CaesarsCaesars

Seahawks vs. 49ers: Detailed Breakdown

Matchup overview: NFL Week 12

  • Teams: Seattle Seahawks vs. San Francisco 49ers
  • Date: Sunday, November 29, 2026
  • Time: 4:25PM ET
  • Venue: Levi's Stadium

Current betting odds

  • Spread: Seahawks (+1.5, -120), 49ers (-1.5, -110)
  • Moneyline: Seahawks -110, 49ers -121
  • Total (Over/Under): 47.5 points (-115/-115)

Dimers’ win probabilities

  • Seahawks: 47.5%
  • 49ers: 52.5%

These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this NFL matchup is Seahawks 23-23 49ers.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.

Our Prediction: Who Wins?

The numbers give the Seahawks a win probability of 47.5%, while the 49ers have a win probability of 52.5%.

Summary

The Seahawks face off against the 49ers in the NFL at Levi's Stadium on Sunday, November 29, 2026.

Our Seahawks vs. 49ers predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.