NFL best bets today: Week 11 picks include 49ers vs. Cardinals play [11/16/2025]

Updated: November 16, 2025, 4:05 PM ET | First published: November 16, 2025, 12:02 AM ET

Written by Ryan Leaver, Senior Editor

Get NFL best bets and predictions for Sunday, November 16, 2025.

Today’s NFL picks for November 16, 2025 are here, with 49ers vs. Cardinals and Ravens vs. Browns among the top plays identified by our model across Sunday’s NFL slate.

Dimers’ predictive analytics engine runs 24/7, searching the latest football odds to uncover top betting edges. The result? Data-backed plays that help Dimers Pro members make smarter decisions.

List of NFL best bets today [11/16, updated 4:05PM ET]

On the back of a recent review of our NFL model's results, you’ll find today’s best football bets, ranked by edge for Sunday, November 16, 2025.

Cardinals +3.5 (-105)

Edge: 7.7%
Probability: 58.9%
Matchup: 49ers vs. Cardinals (4:05PM ET, Sunday)

Our model has identified value on Cardinals +3.5 at -105 odds. A 58.9% probability produces an edge of 7.7%, making this the strongest play for today's NFL slate.

Browns +7.5 (-110)

Edge: 3.4%
Probability: 55.8%
Matchup: Ravens vs. Browns (4:25PM ET, Sunday)

Browns +7.5 carries a 3.4% edge and a probability of 55.8% at -110 odds, according to our model.

Seahawks +3.5 (-115)

Edge: 3.0%
Probability: 56.5%
Matchup: Seahawks vs. Rams (4:05PM ET, Sunday)

Seahawks +3.5 vs. Rams at -115 odds shows a 3.0% edge, supported by a 56.5% probability in simulations.

NFL best bets summary: Sunday, 11/16/2025

As of 4:05PM ET, here are our top NFL bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
49ers vs. Cardinals	Cardinals +3.5	-105 @ BetMGM	7.7%	58.9%
Ravens vs. Browns	Browns +7.5	-110 @ BetMGM	3.4%	55.8%
Seahawks vs. Rams	Seahawks +3.5	-115 @ BetMGM	3.0%	56.5%

List of upcoming NFL games to bet on [11/16/2025]

49ers vs. Cardinals (4:05PM ET, Sunday)
Seahawks vs. Rams (4:05PM ET, Sunday)
Chiefs vs. Broncos (4:25PM ET, Sunday)
Ravens vs. Browns (4:25PM ET, Sunday)
Lions vs. Eagles (8:20PM ET, Sunday)

Elevate Your Betting Game With Dimers Pro

Discover the difference our best bets make with Dimers Pro. Check out this explainer video to see how you can gain an edge.

NFL betting promos for Week 11

Make the most of our best bets today—including Cardinals +3.5—with the two offers listed below.

DraftKings Sportsbook

Bet365 Sportsbook

Join Bet365 Sportsbookwith the bonus code "DIMERS" to unlock $200 in bonus bets.

Conclusion

Our NFL best bets are locked and loaded for November 16, 2025, featuring plays such as Cardinals +3.5 and Browns +7.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.

Written by

Ryan Leaver

Senior Editor

Ryan Leaver specializes in sports betting analysis across the NBA, NFL, college football, college basketball, and soccer. Drawing on advanced statistical models, simulations, and historical data, he produces game previews, betting picks, player prop analysis, and futures coverage to help bettors make more informed decisions.

Advertiser disclosure