Los Angeles Rams vs. Arizona Cardinals: Experts release early Week 10 predictions [2026]

The Los Angeles Rams and Arizona Cardinals will meet in Week 10 of the NFL season at State Farm Stadium on Sunday, November 15, 2026, starting at 4:05 PM ET.

Initial simulations from Dimers' trusted NFL model favor the Rams as the most likely winner of this NFC West rivalry matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Rams vs. Cardinals predictions page.

LA Rams vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Rams vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Rams 74.1%, Cardinals 25.9%
• Predicted final score: Rams 26-19 Cardinals
• Spread: Rams (-7.5) 50.0%, Cardinals (+7.5) 50.0%
• Total points (45): Over 51.0%, Under 49.0%

As of November 9, 2026, these Rams-Cardinals calculations and predictions reflect the latest data and insights available.

Rams vs. Cardinals Week 10 details

Sunday's game between the Cardinals and Rams at State Farm Stadium is scheduled for November 15, 2026.

• Who: Los Angeles Rams vs. Arizona Cardinals
• Date: Sunday, November 15, 2026
• Time: 4:05 PM ET/1:05 PM PT
• Venue: State Farm Stadium

Rams vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 10 game, which are listed here:

• Spread: Rams -7.5 (+102), Cardinals +7.5 (-107)
• Moneyline: Rams -310, Cardinals +317
• Total: Over/Under 45 (-108/-106)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Rams, with a 74.1% win probability, will likely beat the Cardinals in Week 10 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Rams vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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