New York Giants vs. Detroit Lions: Experts release early Week 12 preview [2025]

The New York Giants and Detroit Lions will meet in Week 12 of the NFL season at Ford Field on Sunday, November 23, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Lions as the most likely winner of this NFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Giants vs. Lions predictions page.

NY Giants vs. Detroit early predictions

Leveraging trusted machine learning and analysis, we have simulated the Giants vs. Lions game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Giants 20%, Lions 80%
• Predicted final score: Giants 19-29 Lions
• Spread: Giants (+10.5) 54%, Lions (-10.5) 46%
• Total points (50.5): Over 48%, Under 52%

As of November 17, 2025, these Giants-Lions calculations and predictions reflect the latest data and insights available.

Giants vs. Lions Week 12 details

The NFL Week 12 action between the Lions and Giants at Ford Field is scheduled for November 23, 2025.

• Who: New York Giants vs. Detroit Lions
• Date: Sunday, November 23, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Ford Field

Giants vs. Lions opening odds

We've researched the best betting odds across America for this Week 12 game, which are listed here:

• Spread: Giants +10.5 (-102), Lions -10.5 (-110)
• Moneyline: Giants +500, Lions -550
• Total: Over/Under 50.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Lions, with an 80% win probability, will likely beat the Giants in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Giants vs. Lions game, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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