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Clemson vs. Louisville prediction: Louisville favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Clemson vs Louisville predictions for college football Friday.
Louisville and Clemson will meet in Week 12 college football action at L&N Federal Credit Union Stadium on Friday, commencing at 7:30PM ET.
Based on updated simulations, Dimers' proven college football model predicts Louisville as the most likely winner of the Clemson vs. Louisville game.
This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.
Clemson vs. Louisville prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Clemson vs. Louisville 10,000 times as part of our college football predictions coverage.
Our leading predictive model gives Louisville a 55% chance of defeating Clemson. Our predicted final score has Louisville winning 26-24.
According to our model, the bookmakers have got it right, and Clemson and Louisville each have a 50% chance of covering the spread, while the over/under total of 50.5 points has a 51% chance of going over.
Clemson vs. Louisville odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | Clemson | Louisville |
|---|---|---|
| Spread | +1.5 (-105) | -1.5 (-115) |
| Moneyline | +106 | -122 |
| Total | o50.5 (-115) | u50.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Clemson vs. Louisville picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Clemson +1.5 | -105 |
| Moneyline | Louisville | -122 |
| Total | Over 50.5 | -115 |
According to our college football best bets, the top play to make on this game is Louisville to win.
Clemson vs. Louisville game-day updates and essential details
Friday's college football action between Louisville and Clemson at L&N Federal Credit Union Stadium is scheduled to commence at 7:30PM ET.
- Who: Clemson vs. Louisville
- Date: Friday, November 14, 2025
- Time: 7:30PM ET/4:30PM PT
- Venue: L&N Federal Credit Union Stadium
Conclusion
We predict Louisville, with a 55% win probability, will likely beat Clemson on Friday.
AI and automation have enhanced this article to quickly deliver accurate Clemson vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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