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Cardinals vs. Colts prediction: Why Indianapolis is favored to win in NFL Week 6, 2025
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Arizona Cardinals vs Indianapolis Colts predictions for NFL Sunday.
The Indianapolis Colts will square off with the Arizona Cardinals in NFL Week 6 action at Lucas Oil Stadium on Sunday, beginning at 1:00PM ET.
Based on the latest simulations, Dimers' proven NFL model projects the Colts as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Colts game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Colts with a win probability of 78%, while the Cardinals have 22%."
This gameday Cardinals vs. Colts betting preview builds on my Cardinals vs. Colts prediction that was released earlier in the week.
For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive Cardinals vs. Colts predictions page.
Cardinals vs. Colts predictions
Since our Cardinals-Colts predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Cardinals and Colts 10,000 times as part of our NFL predictions coverage.
Our independent predictive model currently gives the Colts a 78% chance of defeating the Cardinals in Week 6 of the NFL season. Our predicted final score has the Colts winning 26-18.
According to our model, the Cardinals (+9.5) have a 53% chance of covering the spread, while the 46.5-point over/under has a 53% chance of staying under.
To see win probabilities for every matchup this week, check out our expert NFL Week 6 straight up picks.
Cardinals vs. Colts odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | Cardinals | Colts |
|---|---|---|
| Spread | +9.5 (-115) | -9.5 (-110) |
| Moneyline | +375 | -430 |
| Total | o46.5 (+102) | u46.5 (-105) |
All odds are correct at the time of publication and are subject to change.
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Cardinals vs. Colts picks and best bets
Our model's biggest edge in today's Cardinals vs. Colts matchup is on the spread.
Our expert predictions, aligned with the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Cardinals vs. Colts TD scorers
Who will score an anytime touchdown in Cardinals vs. Colts?
According to our list of touchdown scorer predictions for Week 6, Indianapolis' Jonathan Taylor is most likely to score the first touchdown in Cardinals vs. Colts.
Our projections give Taylor a 19.9% chance of getting in for six first at Lucas Oil Stadium, while the Colts running back is a 63.4% chance of scoring an anytime touchdown.
First touchdown scorer predictions
Arizona Cardinals
| Player | First TD Probability |
|---|---|
| Bam Knight (RB) | 6.8% |
| Marvin Harrison (WR) | 6.4% |
| Michael Carter (RB) | 5.6% |
Indianapolis Colts
| Player | First TD Probability |
|---|---|
| Jonathan Taylor (RB) | 19.9% |
| Daniel Jones (QB) | 7.4% |
| Tyler Warren (TE) | 7.0% |
Anytime touchdown scorer predictions
Arizona Cardinals
| Player | Anytime TD Probability |
|---|---|
| Bam Knight (RB) | 31.5% |
| Marvin Harrison (WR) | 30.2% |
| Michael Carter (RB) | 26.9% |
Indianapolis Colts
| Player | Anytime TD Probability |
|---|---|
| Jonathan Taylor (RB) | 63.4% |
| Daniel Jones (QB) | 31.3% |
| Tyler Warren (TE) | 29.7% |
Cardinals vs Colts player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Colts. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 6 games.
Cardinals vs. Colts quarterbacks
Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected to throw for fewer yards than the Colts' Daniel Jones.
Cardinals rushing
Bam Knight, Michael Carter and Jacoby Brissett are projected to be the leading rushers for the Cardinals.
| Player | Position |
|---|---|
| Bam Knight | RB |
| Michael Carter | RB |
| Jacoby Brissett | QB |
Colts rushing
Jonathan Taylor, Daniel Jones and DJ Giddens are expected to lead the Colts in rushing yards.
| Player | Position |
|---|---|
| Jonathan Taylor | RB |
| Daniel Jones | QB |
| DJ Giddens | RB |
Cardinals receiving
Trey McBride, Marvin Harrison, Michael Wilson, Zay Jones and Greg Dortch are projected to top the receiving yards for the Cardinals.
| Player | Position |
|---|---|
| Trey McBride | TE |
| Marvin Harrison | WR |
| Michael Wilson | WR |
| Zay Jones | WR |
| Greg Dortch | WR |
Colts receiving
Michael Pittman, Tyler Warren, Josh Downs, Alec Pierce and Jonathan Taylor are projected to lead the Colts in receiving yards.
| Player | Position |
|---|---|
| Michael Pittman | WR |
| Tyler Warren | TE |
| Josh Downs | WR |
| Alec Pierce | WR |
| Jonathan Taylor | RB |
Cardinals vs. Colts game-day updates and essential details
The NFL Week 6 matchup between the Colts and Cardinals at Lucas Oil Stadium is scheduled to commence at 1:00PM ET.
- Who: Arizona Cardinals vs. Indianapolis Colts
- Date: Sunday, October 12, 2025
- Time: 1:00PM ET/10:00AM PT
- Venue: Lucas Oil Stadium
Dimers' in-depth preview of this week's Cardinals vs. Colts matchup includes our prediction, picks and the latest betting odds.
Before making any Cardinals vs. Colts picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Colts, with a 78% win probability, will likely beat the Cardinals in Week 6 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Colts insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NFL
Keep up with the latest NFL betting news and NFL parlay picks throughout the season. Plus, our Super Bowl odds offer the latest projections for the Super Bowl, AFC, NFC and each division.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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