Arizona Cardinals vs. Indianapolis Colts updated prediction featuring Michael Carter, Jonathan Taylor [Week 6, 2025]

Dimers' latest NFL predictions are live for Indianapolis Colts and Arizona Cardinals in Week 6, with our model giving the Colts a 74% of winning against the Cardinals on Sunday.

This update builds on our early Colts-Cardinals predictions, producing fresh win probabilities, score projections, and TD predictions for Michael Carter, Jonathan Taylor, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Cardinals vs. Colts page.

What's changed? Arizona vs. Indianapolis updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Cardinals vs. Colts matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Cardinals 26%, Colts 74%
• Predicted Final Score: Cardinals 19-26 Colts
• Spread: Cardinals (+7) 50%, Colts (-7) 50%
• Total Points (46.5): Over 50%, Under 50%

As of October 9, 2025, these Cardinals-Colts calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 6 highlight the top candidates to find the end zone in Cardinals-Colts on Sunday:

Arizona Cardinals

• Michael Carter: 35.3% probability
• Marvin Harrison: 32.0% probability
• Trey McBride: 26.5% probability

Indianapolis Colts

• Jonathan Taylor: 60.9% probability
• Tyler Warren: 30.9% probability
• Daniel Jones: 29.6% probability

Cardinals vs. Colts latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Cardinals +7 (-105), Colts -7 (-110)
• Moneyline: Cardinals +290, Colts -345
• Total: Over/Under 46.5 (-115/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Cardinals vs. Colts Week 6 details

The NFL Week 6 game between the Colts and Cardinals at Lucas Oil Stadium is scheduled for October 12, 2025.

• Who: Arizona Cardinals vs. Indianapolis Colts
• Date: Sunday, October 12, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

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Conclusion

We predict the Colts, with a 74% win probability, will likely beat the Cardinals in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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