Charlotte FC vs. Chicago Fire prediction, odds, MLS picks [9/26/2026]

Charlotte will face Chicago in MLS action at Bank of America Stadium on Saturday, starting at 7:30 PM ET.

Dimers' proven MLS model projects Charlotte as the most likely winner in this Charlotte vs. Chicago prediction.

This article offers further insights into Saturday's match, including best bets and picks.

Charlotte FC vs. Chicago Fire prediction and odds

Using trusted machine learning and statistical analysis, we have re-simulated the result of Saturday's MLS matchup between Charlotte and Chicago, forming part of our MLS predictions coverage.

Our leading predictive model currently indicates a 52.0% chance of Charlotte winning, a 26.2% chance for Chicago, and a 21.8% chance of a draw. Additionally, the 2.5-goal over/under has a 64.8% chance of going over., according to our model.

Latest betting odds

We have sourced the best MLS odds in America for this game, which are listed here:

• Moneyline: Chicago +213, Charlotte +122
• Total Goals: Over/Under 2.5 (-194/+194)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Charlotte @ +122 via Polymarket
• Total Goals: Under 2.5 @ +194 via Polymarket

According to our MLS best bets, the top play to make on this game is Charlotte to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score projections

Here are the top three most likely final scores according to our model, with a 2-1 Charlotte win being the most probable:

• Charlotte 2-1 Chicago (9.5% probability)
• Charlotte 1-1 Chicago (9.5%)
• Charlotte 2-0 Chicago (7%)

Game info & kickoff details

Saturday's MLS matchup between Charlotte and Chicago in MLS at Bank of America Stadium is scheduled to commence at 7:30 PM ET.

• Who: Charlotte FC vs. Chicago Fire
• Date: Saturday, September 26, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Bank of America Stadium

Conclusion

According to our computer model, Charlotte has a 52.0% win probability on Saturday, Chicago has a 26.2% win probability, and there is a 21.8% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary MLS prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.