Giants vs. Cardinals: MLB Prediction & Analysis

Our detailed prediction and analysis for the Giants vs. Cardinals MLB game on Wednesday, September 16, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
FINAL
MLB sport icon
MLB
Giants
Anthony Molina 3-1, 5.24 ERA
6
5
Busch Stadium
Cardinals
Matthew Liberatore 5-14, 5.53 ERA
Busch Stadium
2 3 4 5 6 7 8 9 10 RHE
Giants
0 1 0 0 0 2 1 0 2 6 13 2
Cardinals
0 0 0 0 0 2 0 2 1 5 5 2
Live Probabilities
Win %
  • Giants
    100%
  • Cardinals
    0%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Nathan Church flies out to deep right center field to Grant McCray.
Quick Box Score
Giants Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Cox 2B4131011.7501.550
2 G. McCray RF0100000.0000.000
3 D. Gilbert CF11121001.0005.000
4 J. H. Lee DH4000011.0000.200
5 S. Whitcomb 1B5120000.4000.800
6 T. Hill LF5010000.2000.400
7 A. Knizner C4131000.7501.550
8 O. Basabe 3B0000000.0000.000
9 C. Koss SS4110001.2500.500
Cardinals Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Fermín LF1001000.0000.000
2 L. Bernal C5011002.2000.400
3 A. Burleson 1B5110002.2000.600
4 J. Walker RF3100022.0000.400
5 V. Scott PR0000000.0000.000
6 N. Gorman 3B3100020.0000.400
7 T. Saggese 2B4211001.2500.450
8 N. Church CF5020001.4000.800
9 M. Winn SS0000000.0000.000

Giants vs. Cardinals: Detailed Breakdown

Matchup overview: MLB Wednesday

  • Teams: San Francisco Giants vs. St. Louis Cardinals
  • Date: Wednesday, September 16, 2026
  • Time: 1:15PM ET
  • Venue: Busch Stadium

Current betting odds

  • Spread: Giants (+1.5, -144), Cardinals (-1.5, +145)
  • Moneyline: Giants +147, Cardinals -150
  • Total (Over/Under): 8.5 runs (+111/-108)

Dimers’ win probabilities

  • Giants: 40.6%
  • Cardinals: 59.4%

Dimers' predictive MLB model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Giants a win probability of 40.6%, while the Cardinals have a win probability of 59.4%.

Summary

According to our analysis, the Cardinals are more likely to beat the Giants in the MLB game at Busch Stadium on Wednesday. Discover the best run line, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Giants vs. Cardinals predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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