White Sox vs. Guardians: MLB Prediction & Analysis

Our detailed prediction and analysis for the White Sox vs. Guardians MLB game on Wednesday, September 16, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
FINAL
MLB sport icon
MLB
White Sox
Anthony Kay 9-9, 4.53 ERA
3
6
Progressive Field
Guardians
Parker Messick 11-9, 2.51 ERA
Progressive Field
1 2 3 4 5 6 7 8 9 RHE
White Sox
0 0 0 0 3 0 0 0 0 3 8 1
Guardians
0 0 2 0 0 4 0 0 X 6 5 0
Live Probabilities
Win %
  • White Sox
    0%
  • Guardians
    100%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Randal Grichuk strikes out swinging.
Quick Box Score
White Sox Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 C. Meidroth SS5130000.6001.400
2 R. Grichuk LF5120001.4001.200
3 M. Vargas 3B4010001.2500.500
4 T. Pham DH4113101.2501.250
5 K. Teel C3000012.0000.250
6 B. Doyle CF4010002.2500.500
7 M. Murakami 1B1000010.0000.500
8 S. Antonacci 2B1000000.0000.000
9 T. Peters RF4000001.0000.000
Guardians Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 S. Kwan LF3100010.0000.250
2 J. Ramírez 3B4021000.5001.500
3 J. Adell RF3012012.3330.833
4 T. Bazzana DH4000000.0000.000
5 N. Lowe 1B0000000.0000.000
6 A. Genao 2B3000011.0000.250
7 A. Hedges C3100011.0000.250
8 P. Halpin CF4223100.5001.750
9 B. Rocchio SS3100011.0000.250

White Sox vs. Guardians: Detailed Breakdown

Matchup overview: MLB Wednesday

  • Teams: CHI White Sox White Sox vs. Cleveland Guardians
  • Date: Wednesday, September 16, 2026
  • Time: 1:10PM ET
  • Venue: Progressive Field

Current betting odds

  • Spread: White Sox (+1.5, -156), Guardians (-1.5, +153)
  • Moneyline: White Sox +144, Guardians -150
  • Total (Over/Under): 6.5 runs (-120/+115)

Dimers’ win probabilities

  • White Sox: 42.5%
  • Guardians: 57.5%

Dimers' predictive MLB model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the White Sox a win probability of 42.5%, while the Guardians have a win probability of 57.5%.

Summary

According to our analysis, the Guardians are more likely to beat the White Sox in the MLB game at Progressive Field on Wednesday. Discover the best run line, over/under and moneyline odds, picks and probabilities for the game on this page.

Our White Sox vs. Guardians predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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