Sep 16, 2026
Giants vs. Cardinals prediction: St. Louis favored to win Wednesday's MLB matchup [9/16/2026]
Read Article Yankees vs. Twins prediction: Why Yankees are favored to win Wednesday's MLB matchup [9/16/2026]
Updated: | First published:
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Written by Jason Bevilacqua, Head of Content and Communities
Dimers' simulation model projects a 53.5% win probability for the Yankees at Target Field.
The Minnesota Twins and New York Yankees are scheduled to meet in MLB action at Target Field on Wednesday, starting at 1:40 PM ET.
Zebby Matthews (9-10, 4.98 ERA) will start on the mound for the Twins, while the Yankees have opted for Carlos Rodón (6-3, 2.94 ERA).
Dimers' proven MLB model gives the Yankees a slight edge with a 53.5% win probability over the Twins.
This article offers a complete Yankees vs. Twins prediction, including best bets and picks.
Yankees vs. Twins prediction and odds
Using trusted machine learning and data analysis, we have re-simulated the outcome of Wednesday's MLB game between the Yankees and Twins, forming part of our MLB predictions coverage.
Our famous predictive model gives the Yankees a 53.5% chance of defeating the Twins. According to our model, the Twins (+1.5) have a 59.6% chance of covering the run line, while the over/under total of 8.5 runs has a 51.5% chance of going over.
Latest betting odds
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Yankees -1.5 (+125) / Twins +1.5 (-117)
- Moneyline: Yankees -140, Twins +144
- Total: Over/Under 8.5 (+113/-115)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Twins +1.5 @ 54¢ via Novig
- Moneyline: Twins @ 41¢ via Novig
- Total: Over 8.5 @ 47¢ via Polymarket
According to our MLB best bets, the top play to make on this game is Twins +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Wednesday's MLB action between the Twins and Yankees at Target Field is scheduled to commence at 1:40 PM ET.
- Who: New York Yankees vs. Minnesota Twins
- Date: Wednesday, September 16, 2026
- Time: 1:40 PM ET/10:40AM PT
- Venue: Target Field
Conclusion
We predict the Yankees, with a 53.5% win probability, will likely beat the Twins in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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