MLB picks today: Wednesday's MLB best bets include Dodgers vs. Reds play [9/16/2026]

Dodgers vs. Reds Over 8.5 runs (-104)

• Edge: 5.8%
• Probability: 56.8%
• Matchup: Dodgers vs. Reds (6:40PM ET)

Our model has identified value on Over 8.5 runs in Dodgers vs. Reds at 51¢ odds. A 56.8% probability produces an edge of 5.8%, making this the strongest play for today's MLB slate.

Braves vs. Cubs Over 7.5 runs (-115)

• Edge: 5.5%
• Probability: 59%
• Matchup: Braves vs. Cubs (7:40PM ET)

Braves vs. Cubs over 7.5 runs carries a 5.5% edge and a probability of 59% at 53¢ odds, according to our model.

Marlins vs. Diamondbacks Over 8.5 runs (-122)

• Edge: 5.4%
• Probability: 60.3%
• Matchup: Marlins vs. Diamondbacks (9:40PM ET)

Marlins vs. Diamondbacks Over 8.5 runs at 55¢ odds shows a 5.4% edge, supported by a 60.3% probability in simulations.

Yankees vs. Twins over 8.5 runs (+113)

• Edge: 5.3%
• Probability: 52.3%
• Matchup: Yankees vs. Twins (1:40PM ET)

A 5.3% edge and 52.3% probability make Yankees vs. Twins over 8.5 runs a value play in the Yankees vs. Twins matchup, per our model.

Red Sox vs. Rangers Over 8.5 runs (+113)

• Edge: 5.3%
• Probability: 52.3%
• Matchup: Red Sox vs. Rangers (8:05PM ET)

Red Sox vs. Rangers Over 8.5 runs at 47¢ presents a 5.3% edge, with simulations resulting in a probability of 52.3%.

Twins +1.5 (-125)

• Edge: 5.3%
• Probability: 60.9%
• Matchup: Yankees vs. Twins (1:40PM ET)

Our model finds value on Twins +1.5 at 56¢, supported by an edge of 5.3%.

Diamondbacks -1.5 (+163)

• Edge: 5.1%
• Probability: 43.1%
• Matchup: Marlins vs. Diamondbacks (9:40PM ET)

Our model has uncovered value on Diamondbacks -1.5 at 38¢. A 43.1% probability produces a 5.1% edge, making this a strong play for today's MLB action.

Twins ML (+133)

• Edge: 4.9%
• Probability: 45.5%
• Matchup: Yankees vs. Twins (1:40PM ET)

A 4.9% edge on a 45.5% probability makes Twins to win at +133a solid value play in today's Yankees vs. Twins matchup.

Athletics vs. RaysOver 7.5 runs (-113)

• Edge: 4.7%
• Probability: 57.7%
• Matchup: Athletics vs. Rays (6:40PM ET)

Our model projects value on Over 7.5 runs at 53¢. A 57.7% probability produces a 4.7% edge, making the Over the favorable side in today's matchup.

Athletics ML (+170)

• Edge: 4.1%
• Probability: 41.1%
• Matchup: Athletics vs. Rays (6:40PM ET)

Rounding out our top 10 bets, Athletics to defeat Rays at 37¢ shows a 41.1% probability and a 4.1% edge.

MLB best bets summary: Wednesday, 9/16/2026

As of 12:36AM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [9/16/2026]

• Giants vs. Cardinals (1:15PM ET, Wednesday)
• Yankees vs. Twins (1:40PM ET, Wednesday)
• Tigers vs. Blue Jays (3:07PM ET, Wednesday)
• Athletics vs. Rays (6:40PM ET, Wednesday)
• Dodgers vs. Reds (6:40PM ET, Wednesday)
• Brewers vs. Pirates (6:40PM ET, Wednesday)
• Phillies vs. Nationals (6:45PM ET, Wednesday)
• Orioles vs. Mets (7:10PM ET, Wednesday)
• Braves vs. Cubs (7:40PM ET, Wednesday)
• Red Sox vs. Rangers (8:05PM ET, Wednesday)
• Royals vs. Astros (8:10PM ET, Wednesday)
• Padres vs. Rockies (8:40PM ET, Wednesday)
• Mariners vs. Angels (9:38PM ET, Wednesday)
• Marlins vs. D-Backs (9:40PM ET, Wednesday)

Conclusion

Our MLB best bets are locked and loaded for September 16, 2026, featuring plays such as over 8.5 runs in the Dodgers vs. Reds matchup and over 7.5 runs in the Braves vs. Cubs matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.