MLB picks today: Saturday's MLB best bets include Rockies vs. White Sox play [9/26/2026]

Rockies vs. White Sox Over 8.5 runs (+108)

• Edge: 5.0%
• Probability: 53.1%
• Matchup: Rockies vs. White Sox (7:10PM ET)

Our model has identified value on Over 8.5 runs in Rockies vs. White Sox at 48¢ odds. A 53.1% probability produces an edge of 5.0%, making this the strongest play for today's MLB slate.

Reds vs. Blue Jays Over 7.5 runs (-117)

• Edge: 4.9%
• Probability: 58.8%
• Matchup: Reds vs. Blue Jays (3:07PM ET)

Reds vs. Blue Jays over 7.5 runs carries a 4.9% edge and a probability of 58.8% at 54¢ odds, according to our model.

Dodgers vs. Giants Over 7.5 runs (+106)

• Edge: 4.6%
• Probability: 53.1%
• Matchup: Dodgers vs. Giants (4:05PM ET)

Dodgers vs. Giants Over 7.5 runs at +106 odds shows a 4.6% edge, supported by a 53.1% probability in simulations.

Cardinals vs. Brewers over 7.5 runs (-108)

• Edge: 3.9%
• Probability: 55.9%
• Matchup: Cardinals vs. Brewers (7:10PM ET)

A 3.9% edge and 55.9% probability make Cardinals vs. Brewers over 7.5 runs a value play in the Cardinals vs. Brewers matchup, per our model.

Pirates ML (+108)

• Edge: 3.8%
• Probability: 50.9%
• Matchup: Pirates vs. Tigers (1:10PM ET)

Pirates ML at 48¢ presents a 3.8% edge, with simulations resulting in a probability of 50.9%.

Giants ML (+285)

• Edge: 3.7%
• Probability: 29.7%
• Matchup: Dodgers vs. Giants (4:05PM ET)

Our model finds value on Giants to win at 26¢, supported by an edge of 3.7%.

Giants +1.5 (+156)

• Edge: 3.5%
• Probability: 42.6%
• Matchup: Dodgers vs. Giants (4:05PM ET)

Our model has uncovered value on Giants +1.5 at 39¢. A 42.6% probability produces a 3.5% edge, making this a strong play for today's MLB action.

Cardinals ML (+178)

• Edge: 3.3%
• Probability: 39.1%
• Matchup: Cardinals vs. Brewers (7:10PM ET)

A 3.3% edge on a 39.1% probability makes Cardinals to win at 36¢a solid value play in today's Cardinals vs. Brewers matchup.

Angels vs. MarinersOver 7.5 runs (-106)

• Edge: 3.3%
• Probability: 54.8%
• Matchup: Angels vs. Mariners (9:40PM ET)

Our model projects value on Over 7.5 runs at 51¢. A 54.8% probability produces a 3.3% edge, making the Over the favorable side in today's matchup.

Braves vs. Marlins Over 8.5 runs (-108)

• Edge: 3.2%
• Probability: 55.1%
• Matchup: Braves vs. Marlins (4:10PM ET)

Rounding out our top 10 bets, Braves vs. Marlins Over 8.5 runs at 52¢ shows a 55.1% probability and a 3.2% edge.

MLB best bets summary: Saturday, 9/26/2026

As of 12:34AM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [9/26/2026]

• Mets vs. Nationals (12:35PM ET, Saturday)
• Pirates vs. Tigers (1:10PM ET, Saturday)
• Reds vs. Blue Jays (3:07PM ET, Saturday)
• Dodgers vs. Giants (4:05PM ET, Saturday)
• Braves vs. Marlins (4:10PM ET, Saturday)
• Cardinals vs. Brewers (7:10PM ET, Saturday)
• Rockies vs. White Sox (7:10PM ET, Saturday)
• Guardians vs. Royals (7:10PM ET, Saturday)
• Angels vs. Mariners (9:40PM ET, Saturday)

Conclusion

Our MLB best bets are locked and loaded for September 26, 2026, featuring plays such as over 8.5 runs in the Rockies vs. White Sox matchup and over 7.5 runs in the Reds vs. Blue Jays matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.