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Read Article Diamondbacks vs. Pirates prediction: Why Pittsburgh is favored to win Wednesday's MLB matchup [7/29/2026]
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Written by Dave Garofolo, Content Producer
Get Arizona Diamondbacks vs Pittsburgh Pirates predictions for MLB Wednesday.
The Pittsburgh Pirates and Arizona dbacks will lock horns in MLB action at PNC Park on Wednesday, starting at 12:35 PM ET.
The Pirates will send Jared Jones (2-1, 3.72 ERA) to the mound, while the Diamondbacks have opted for Eduardo Rodriguez (9-3, 2.64 ERA).
Dimers' advanced MLB model gives the Pirates a slight edge with a 54.0% win probability over the Diamondbacks.
This article offers a closer look at Wednesday's Diamondbacks vs. Pirates matchup, including best bets and picks.
Diamondbacks vs. Pirates prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Diamondbacks and Pirates, forming part of our MLB predictions coverage.
Our famous predictive model gives the Pirates a 54.0% chance of defeating the Diamondbacks.
According to our model, the Diamondbacks (+1.5) have a 62.3% chance of covering the run line, while the over/under total of 8.5 runs has a 55.4% chance of going over,.
Diamondbacks vs. Pirates odds [7/29/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Diamondbacks | Pirates |
|---|---|---|
| Run Line | +1.5 (-156) | -1.5 (+156) |
| Moneyline | +127 | -130 |
| Total | o8.5 (-108) | u8.5 (+108) |
All odds are correct at the time of publication and are subject to change.
Diamondbacks vs. Pirates picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Diamondbacks +1.5 | -156 |
| Moneyline | Diamondbacks | +127 |
| Total | Over 8.5 | -108 |
According to our best MLB bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Diamondbacks vs. Pirates game-day updates and essential details
Wednesday's MLB game between the Pirates and Diamondbacks at PNC Park is scheduled to commence at 12:35 PM ET.
- Who: Arizona Diamondbacks vs. Pittsburgh Pirates
- Date: Wednesday, July 29, 2026
- Time: 12:35 PM ET/9:35AM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 54.0% win probability, will likely beat the Diamondbacks in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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