Santos Laguna vs. Pumas UNAM prediction, odds, Liga MX picks [10/21/2026]

Using powerful machine learning and statistical analysis, we have re-simulated the outcome of Wednesday's Liga MX game between Santos Laguna and Pumas UNAM, forming part of our Liga MX predictions coverage.

Our leading predictive model suggests a 33.0% chance of Santos Laguna winning, a 41.6% chance for Pumas UNAM, and a 25.4% chance of a draw. Additionally, the over/under total of 2.5 goals has a 51.8% chance of going over., with a 55.6% chance that both teams score.

Latest betting odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Pumas UNAM +195, Santos Laguna +130
• Total Goals: Over/Under 2.5 (-184/+142)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Pumas UNAM @ +195 via DraftKings
• Total Goals: Under 2.5 @ +142 via FanDuel

According to our Liga MX best bets, the top play to make on this game is Pumas UNAM to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score and BTTS projections

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

• Santos Laguna 1-1 Pumas UNAM (12% probability)
• Santos Laguna 0-1 Pumas UNAM (9.4%)
• Santos Laguna 1-2 Pumas UNAM (8.8%)

When it comes to the both teams to score (BTTS) market, we project a 55.6% chance of both sides finding the net and a 44.4% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, meaning the most likely correct score may differ from our predicted winner.

Game info & kickoff details

Wednesday's Liga MX game between Santos Laguna and Pumas UNAM is scheduled to begin at 11:10 PM ET.

• Who: Santos Laguna vs. Pumas UNAM
• Date: Wednesday, October 21, 2026
• Time: 11:10 PM ET/8:10 PM PT

Conclusion

According to our computer model, Santos Laguna has a 33.0% win probability on Wednesday, Pumas UNAM has a 41.6% win probability, and there is a 25.4% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Liga MX prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.