Puebla vs. Monterrey prediction, odds, Liga MX picks [10/21/2026]

Using innovative machine learning and data analysis, we have re-simulated the outcome of Wednesday's Liga MX game between Puebla and Monterrey, forming part of our Liga MX predictions coverage.

Our famous predictive model indicates a 26.5% chance of Puebla winning, a 49.9% chance for Monterrey, and a 23.6% chance of a draw. Additionally, the 2.5-goal over/under has a 56.7% chance of going over., with a 58.0% probability that both teams find the net.

Latest betting odds

We have researched the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Monterrey -105, Puebla +255
• Total Goals: Over/Under 2.5 (-130/+104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Monterrey @ -105 via DraftKings
• Total Goals: Over 2.5 @ -130 via DraftKings

According to our best Liga MX bets, the top play to make on this game is Over 2.5 total goals.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score and BTTS projections

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

• Puebla 1-1 Monterrey (11% probability)
• Puebla 1-2 Monterrey (9.6%)
• Puebla 0-1 Monterrey (9.1%)

When it comes to the both teams to score (BTTS) market, we project a 58.0% chance of both sides finding the net and a 42.0% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, meaning the most likely correct score may differ from our predicted winner.

Game info & kickoff details

Wednesday's Liga MX matchup between Puebla and Monterrey is scheduled to start at 9:00 PM ET.

• Who: Puebla vs. Monterrey
• Date: Wednesday, October 21, 2026
• Time: 9:00 PM ET/6:00 PM PT

Conclusion

According to our computer model, Puebla has a 26.5% win probability on Wednesday, Monterrey has a 49.9% win probability, and there is a 23.6% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Liga MX prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.