Wake Forest vs. Louisville prediction favors Louisville to win in college football Week 4 [2026]

Using innovative machine learning and data, we have re-simulated the outcome of Wake Forest vs. Louisville, forming part of our college football predictions coverage.

Our famous predictive model currently gives Louisville an 82.2% chance of defeating Wake Forest. Our predicted final score has Louisville winning 34-22. According to our model, Wake Forest (+12.5) has a 50.7% chance of covering the spread, while the 57.5-point over/under has an equal 50-50 chance of hitting.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Wake Forest +12.5 (-107) / Louisville -12.5 (-105)
• Moneyline: Wake Forest +420, Louisville -520
• Total: Over/Under 57.5 (-105/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Wake Forest +12.5 @ -107 via Caesars
• Moneyline: Wake Forest @ +420 via BetRivers
• Total: Over 57.5 @ -105 via bet365

According to our college football best bets, the top play to make on this game is Wake Forest +12.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Louisville and Wake Forest at L&N Federal Credit Union Stadium is scheduled to start at 12:00 PM ET.

• Who: Wake Forest vs. Louisville
• Date: Saturday, September 26, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: L&N Federal Credit Union Stadium

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Conclusion

We predict Louisville, with an 82.2% win probability, will likely beat Wake Forest in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.