Southern California vs. Penn State prediction: Why Penn State is favored to win in college football Week 6 [2026]

Using innovative machine learning and data, we have re-simulated the outcome of Southern California vs. Penn State, forming part of our college football predictions coverage.

Our leading predictive model gives Penn State a 52.2% chance of defeating Southern California. Our predicted final score has Penn State winning 27-26. According to our model, Southern California (+2.5) has a 52.5% chance of covering the spread, while the over/under total of 54.5 points has a 50.1% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Southern California +2.5 (-114) / Penn State -2.5 (-106)
• Moneyline: Southern California +108, Penn State -124
• Total: Over/Under 54.5 (-110/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern California +2.5 @ -114 via FanDuel
• Moneyline: Southern California @ +108 via bet365
• Total: Under 54.5 @ -106 via Caesars

According to our college football best bets, the top play to make on this game is Southern California to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Penn State and Southern California at West Shore Home Field at Beaver Stadium is scheduled to begin at 7:30 PM ET.

• Who: Southern California vs. Penn State
• Date: Saturday, October 10, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: West Shore Home Field at Beaver Stadium

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Conclusion

We predict Penn State, with a 52.2% win probability, will likely beat Southern California in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.