South Carolina State vs. Charleston Southern prediction: Why South Carolina State is favored to win in college football Week 6 [2026]

Using trusted machine learning and data analysis, we have re-simulated the outcome of South Carolina State vs. Charleston Southern, forming part of our college football predictions coverage.

Our leading predictive model gives South Carolina State a 66.3% chance of defeating Charleston Southern. Our predicted final score has South Carolina State winning 22-17. According to our model, Charleston Southern (+6.5) has a 51.8% chance of covering the spread, while the over/under total of 37.5 points has a 56.3% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: South Carolina State -6.5 (-108) / Charleston Southern +6.5 (-110)
• Moneyline: South Carolina State -221, Charleston Southern +180
• Total: Over/Under 37.5 (-108/-115)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Charleston Southern +6.5 @ -110 via bet365
• Moneyline: Charleston Southern @ +180 via bet365
• Total: Over 37.5 @ -108 via DraftKings

According to our college football best bets, the top play to make on this game is Over 37.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Charleston Southern and South Carolina State at Buccaneer Field is scheduled to begin at 12:00 PM ET.

• Who: South Carolina State vs. Charleston Southern
• Date: Saturday, October 10, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Buccaneer Field

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Conclusion

We predict South Carolina State, with a 66.3% win probability, will likely beat Charleston Southern in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.