Southern Illinois vs. South Dakota prediction favors South Dakota to win in college football Week 6 [2026]

Using powerful machine learning and data analysis, we have re-simulated the outcome of Southern Illinois vs. South Dakota, forming part of our college football predictions coverage.

Our independent predictive model gives South Dakota a 79.3% chance of beating Southern Illinois. Our predicted final score has South Dakota winning 34-23. According to our model, South Dakota (-10.5) has a 52.2% chance of covering the spread, while the over/under total of 58.5 points has a 50.6% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Southern Illinois +10.5 (-121) / South Dakota -10.5 (+100)
• Moneyline: Southern Illinois +295, South Dakota -380
• Total: Over/Under 58.5 (-110/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: South Dakota -10.5 @ +100 via bet365
• Moneyline: South Dakota @ -380 via bet365
• Total: Under 58.5 @ -110 via DraftKings

According to our college football best bets, the top play to make on this game is South Dakota -10.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between South Dakota and Southern Illinois at The DakotaDome is scheduled to begin at 2:00 PM ET.

• Who: Southern Illinois vs. South Dakota
• Date: Saturday, October 10, 2026
• Time: 2:00 PM ET/11:00AM PT
• Venue: The DakotaDome

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Conclusion

We predict South Dakota, with a 79.3% win probability, will likely beat Southern Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.