Southern Illinois vs. South Dakota: College Football Week 6 Prediction, Picks & Odds
Spread
- Southern Illinois
- South Dakota
Southern Illinois vs. South Dakota: Detailed Breakdown
Matchup overview: College Football Week 6
- Teams: Southern Illinois vs. South Dakota
- Date: Saturday, October 10, 2026
- Time: 2:00PM ET
- Venue: The DakotaDome
Current betting odds
- Spread: Southern Illinois (+10.5, -121), South Dakota (-10.5, +100)
- Moneyline: Southern Illinois +295, South Dakota -380
- Total (Over/Under): 58.5 points (-110/-110)
Dimers’ win probabilities
- Southern Illinois: 20.9%
- South Dakota: 79.1%
These probabilities come from two machine learning models that assess more than 100 data points for each college football matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this college football matchup is Southern Illinois 23-34 South Dakota.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models
Our Prediction: Who Wins?
The numbers give the Southern Illinois a win probability of 20.9%, while the South Dakota have a win probability of 79.1%.
Summary
Southern Illinois faces off against South Dakota in college football action at The DakotaDome on Saturday, October 10, 2026.
Our Southern Illinois vs. South Dakota predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.
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