Northwestern vs. Michigan State prediction: Why Northwestern is favored to win in college football Week 7 [2026]

Using powerful machine learning and data analysis, we have re-simulated the result of Northwestern vs. Michigan State, forming part of our college football predictions coverage.

Our leading predictive model currently gives Northwestern a 70.9% chance of defeating Michigan State. Our predicted final score has Northwestern winning 28-22. According to our model, Michigan State (+7.5) has a 51.9% chance of covering the spread, while the over/under total of 49.5 points has a 52.8% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Northwestern -7.5 (-104) / Michigan State +7.5 (-115)
• Moneyline: Northwestern -265, Michigan State +260
• Total: Over/Under 49.5 (-112/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Michigan State +7.5 @ -115 via bet365
• Moneyline: Michigan State @ +260 via BetRivers
• Total: Over 49.5 @ -112 via bet365

According to our college football best bets, the top play to make on this game is Michigan State to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Michigan State and Northwestern at Spartan Stadium is scheduled to commence at 12:00 PM ET.

• Who: Northwestern vs. Michigan State
• Date: Saturday, October 17, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Spartan Stadium

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Conclusion

We predict Northwestern, with a 70.9% win probability, will likely beat Michigan State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.