Luca Van Assche vs. Lorenzo Musetti prediction, odds, picks for ATP Lyon Open 2026

Using powerful machine learning and data analysis, we have re-simulated the result of Friday's Van Assche-Musetti men's singles match, forming part of our tennis predictions coverage.

Our famous predictive model currently gives Musetti a 65% chance of defeating Van Assche at the ATP Lyon Open tournament. Additionally, Musetti has a 61% chance of winning the first set. The simulations also show Van Assche (+3.5) has a 53% chance of covering the games spread, while the under 22.5 games has a 55% chance of hitting, according to our model.

Latest betting odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Lorenzo Musetti -219, Luca Van Assche +200
• First Set: Van Assche +175, Musetti -227

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Van Assche @ +200 via DraftKings
• First Set: Musetti @ -120 via DraftKings

According to our tennis best bets, the top play to make on this match is over 22.5 total games.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The ATP Lyon Open match between Luca Van Assche and Lorenzo Musetti is scheduled to begin on Friday at 2:10 PM ET.

• Who: Luca Van Assche vs. Lorenzo Musetti
• Date: Friday, October 23, 2026
• Approx. Time: 2:10 PM ET/11:10 AM PT
• Tournament: ATP Lyon, France Men's Singles 2026
• Round: Quarterfinals

All dates and times in this article are United States Eastern Time unless otherwise stated.

Conclusion

We predict Lorenzo Musetti, with a 65% win probability, will likely beat Luca Van Assche at the ATP Lyon Open tournament.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Tennis prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.