Flavio Cobolli vs. Lorenzo Musetti prediction, odds, picks for ATP Lyon Open 2026

Using powerful machine learning and data, we have re-simulated the result of Saturday's Cobolli-Musetti men's singles match, forming part of our tennis predictions coverage.

Our famous predictive model currently gives Musetti a 51% chance of winning against Cobolli at the ATP Lyon Open tournament. Additionally, Cobolli has a 51% chance of winning the first set. The simulations also show Musetti (+0.5) has a 53% chance of covering the games spread, while the under 23.5 games has a 56% chance of hitting, according to our model.

Latest betting odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Lorenzo Musetti +100, Flavio Cobolli -115
• First Set: Cobolli +100, Musetti -125

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Musetti @ +100 via DraftKings
• First Set: Musetti @ -130 via DraftKings

According to our tennis best bets, the top play to make on this match is Lorenzo Musetti to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The ATP Lyon Open match between Flavio Cobolli and Lorenzo Musetti is scheduled to commence on Saturday at 10:00 AM ET.

• Who: Flavio Cobolli vs. Lorenzo Musetti
• Date: Saturday, October 24, 2026
• Approx. Time: 10:00 AM ET/7:00 AM PT
• Tournament: ATP Lyon, France Men's Singles 2026
• Round: Semifinals

All dates and times in this article are United States Eastern Time unless otherwise stated.

Conclusion

We predict Lorenzo Musetti, with a 51% win probability, will likely beat Flavio Cobolli at the ATP Lyon Open tournament.

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This article's predictions and probabilities are generated by Dimers' proprietary Tennis prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.