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Patriots vs. Bills Preview and Prediction
Our Patriots vs. Bills preview, analysis and predictions for October 4, 2026, are based on 10,000 NFL game simulations. See Dimers Pro for unlimited access.
NFL
NFL
Patriots
Predicted score
23
:
26
Oct 4, 1:00 PM ET New Highmark Stadium
Bills
Oct 4, 1:00 PM ET New Highmark Stadium
Pre-Game Probabilities Last Update: May 18, 2026, 10:33 PM ET
Spread
- Patriots
- Bills
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Patriots vs. Bills: Detailed Breakdown
Matchup Overview
- Teams: Patriots vs. Bills
- Date: Sunday, October 4, 2026
- Time: 1:00 PM ET
- Venue: New Highmark Stadium
- NFL stats, rosters and injury reports
Current Betting Odds
- Spread: Bills favored at -4
- Total (Over/Under): 50.5
- Moneyline Odds: Patriots +160, Bills -162
Dimers' Win Probabilities
- Patriots: 41%
- Bills: 59%
Dimers' predictive NFL model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.
Projected Final Score
Our predicted final score for this NFL matchup is Patriots 23-26 Bills.
This prediction is based on each team's average score and player stats following 10,000 game simulations.
Our Prediction: Who Wins?
After extensive simulations, our model gives the Patriots a win probability of 41%, while the Bills have a win probability of 59%.
Summary
The Patriots face off against the Bills in the NFL at New Highmark Stadium on Sunday, October 4, 2026. On this page, you'll find our preview, analysis and data-driven projections for the game.
Our Patriots vs. Bills predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL picks, NFL props, NFL futures, NFL odds, and the latest NFL news.