Eagles vs. 49ers: NFL Week 17 Prediction, Picks & Odds

Dimers' Eagles vs. 49ers prediction for Sunday, January 3, 2027. Win probabilities, projected final score, current odds, and picks from our NFL machine learning models.
NFL
NFL sport icon
NFL
Eagles
Predicted score
20
:
25
Levi's Stadium
49ers
Levi's Stadium
Pre-Game Probabilities Last updated:

Spread

49ers -3.0
Spread
  • Eagles
    45.3%
    CaesarsCaesars
  • 49ers
    54.7%
    CaesarsCaesars

Eagles vs. 49ers: Detailed Breakdown

Matchup overview: NFL Week 17

  • Teams: Philadelphia Eagles vs. San Francisco 49ers
  • Date: Sunday, January 3, 2027
  • Time: 8:20PM ET
  • Venue: Levi's Stadium

Current betting odds

  • Spread: Eagles (+3, -120), 49ers (-3, -110)
  • Moneyline: Eagles +150, 49ers -178
  • Total (Over/Under): 46.5 points (-115/-115)

Dimers’ win probabilities

  • Eagles: 34.2%
  • 49ers: 65.8%

These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this NFL matchup is Eagles 20-24 49ers.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models

Our Prediction: Who Wins?

The numbers give the Eagles a win probability of 34.2%, while the 49ers have a win probability of 65.8%.

Summary

The Eagles face off against the 49ers in the NFL at Levi's Stadium on Sunday, January 3, 2027.

Our Eagles vs. 49ers predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.