49ers vs. Dolphins Prediction: San Francisco Predicted to Win in NFL Week 16 [2024]

The Miami Dolphins will take on the San Francisco 49ers in NFL Week 16 action at Hard Rock Stadium on Sunday, commencing at 4:25PM ET.

Based on the latest simulation results, Dimers' proven NFL model (see Dimers Pro for full access) predicts the 49ers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's San Francisco-Miami game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 56%, while the Dolphins have 44%."

This updated 49ers vs. Dolphins betting preview builds on my early 49ers vs. Dolphins prediction that I published at the start of the week.

For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive 49ers vs. Dolphins predictions page.

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49ers vs. Dolphins Game-Day Updates and Essential Details

The NFL Week 16 action between the Dolphins and 49ers at Hard Rock Stadium is scheduled to commence at 4:25PM ET.

• Who: San Francisco 49ers vs. Miami Dolphins
• Date: Sunday, December 22, 2024
• Time: 4:25PM ET/1:25PM PT
• Venue: Hard Rock Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy Dolphins and 49ers gear at Fanatics

Dimers.com's full preview of this week's 49ers vs. Dolphins matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Miami picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

49ers vs. Dolphins Predictions

Using powerful machine learning and statistical analysis, we have simulated the outcome of Sunday's NFL game between the 49ers and Dolphins 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the 49ers a 56% chance of beating the Dolphins in Week 16 of the NFL season. Our predicted final score has the 49ers winning 22-20.

According to our model, the Dolphins (+2) have a 52% chance of covering the spread, while the over/under total of 44.5 points has a 55% chance of staying under.

Along with our 49ers vs. Dolphins predictions, we've also got the following locked and loaded for today’s action:

• NFL Best Bets for Week 16
• NFL Player Props for Week 16
• Anytime TD Scorer Predictions for Week 16

49ers vs. Dolphins Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type	49ers	Dolphins
Spread	-2 (-110)	+2 (-110)
Moneyline	-122	+110
Total	o44.5 (-106)	u44.5 (-114)

All odds are correct at the time of publication and are subject to change.

49ers vs. Dolphins Picks

Our model's strongest edge in today's 49ers vs. Dolphins matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

49ers vs. Dolphins TD Scorers

Who will score the first touchdown in 49ers vs. Dolphins?

According to our model, Miami's De'Von Achane is most likely to score the first TD in 49ers vs. Dolphins.

Our projections give Achane a 12.8% chance of scoring the first TD at Hard Rock Stadium, while the Dolphins RB is a 52.1% chance of reaching the end zone at any point in the game.

First Touchdown Scorer Predictions

San Francisco 49ers

Player	First TD Probability
Patrick Taylor	10.8%
George Kittle	10.0%
Deebo Samuel	9.9%

Miami Dolphins

Player	First TD Probability
De'Von Achane	12.8%
Jonnu Smith	8.0%
Tyreek Hill	7.9%

Anytime Touchdown Scorer Predictions

San Francisco 49ers

Player	Anytime TD Probability
Patrick Taylor	43.0%
George Kittle	41.1%
Jauan Jennings	41.0%

Miami Dolphins

Player	Anytime TD Probability
De'Von Achane	52.1%
Jonnu Smith	35.7%
Tyreek Hill	35.1%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 16 touchdown scorer predictions

49ers vs Dolphins Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Dolphins. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our 49ers-Dolphins page now to access every player prop projection.

49ers vs. Dolphins Quarterbacks

Of the starting quarterbacks, the 49ers' Brock Purdy is projected to throw for more yards than the Dolphins' Tua Tagovailoa.

49ers Rushing

Patrick Taylor, Israel Abanikanda and Brock Purdy are projected to be the leading rushers for the 49ers.

Player	Position
Patrick Taylor	RB
Israel Abanikanda	RB
Brock Purdy	QB

Dolphins Rushing

De'Von Achane, Raheem Mostert and Jaylen Wright are expected to lead the Dolphins in rushing yards.

Player	Position
De'Von Achane	RB
Raheem Mostert	RB
Jaylen Wright	RB

49ers Receiving

George Kittle, Jauan Jennings, Deebo Samuel, Ricky Pearsall and Patrick Taylor are projected to top the receiving yards for the 49ers.

Player	Position
George Kittle	TE
Jauan Jennings	WR
Deebo Samuel	WR
Ricky Pearsall	WR
Patrick Taylor	RB

Dolphins Receiving

Tyreek Hill, Jonnu Smith, Malik Washington, De'Von Achane and River Cracraft are projected to lead the Dolphins in receiving yards.

Player	Position
Tyreek Hill	WR
Jonnu Smith	TE
Malik Washington	WR
De'Von Achane	RB
River Cracraft	WR

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Conclusion

We predict the 49ers, with a 56% win probability, will likely beat the Dolphins in Week 16 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Dolphins insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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