Giants vs. Saints prediction: New Orleans favored to win in NFL Week 5, 2025

The New Orleans Saints and New York Giants will lock horns in Week 5 of the NFL season at Caesars Superdome on Sunday, starting at 1:00PM ET.

Based on the latest simulations, Dimers' proven NFL model projects the Saints as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Giants-Saints game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Saints with a win probability of 56%, while the Giants have 44%."

This gameday Giants vs. Saints betting preview builds on my Giants vs. Saints prediction that was posted earlier in the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Giants vs. Saints predictions page.

Giants vs. Saints Predictions

Since our Giants-Saints predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Giants and Saints 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Saints a 56% chance of defeating the Giants in Week 5 of the NFL season. Our predicted final score has the Saints winning 21-19.

According to our model, the Giants (+2.5) have a 53% chance of covering the spread, while the over/under total of 41.5 points has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 5 straight up picks.

Giants vs. Saints odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Giants	Saints
Spread	+2.5 (-110)	-2.5 (-102)
Moneyline	+118	-130
Total	o41.5 (-115)	u41.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Saints picks and best bets

Our model's strongest edge in today's Giants vs. Saints matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Giants vs. Saints TD scorers

Who will score an anytime touchdown in Giants vs. Saints?

According to our list of touchdown scorer predictions for today, New York's Cam Skattebo is most likely to score the first touchdown in Giants vs. Saints.

Our projections give Skattebo a 15.5% chance of scoring the first TD at Caesars Superdome, while the Giants running back is a 56.6% chance of reaching the end zone at any point during the game.

First touchdown scorer predictions

New York Giants

Player	First TD Probability
Cam Skattebo (RB)	15.5%
Jaxson Dart (QB)	5.9%
Wan'Dale Robinson (WR)	5.8%

New Orleans Saints

Player	First TD Probability
Alvin Kamara (RB)	12.1%
Chris Olave (WR)	6.9%
Juwan Johnson (TE)	6.2%

Anytime touchdown scorer predictions

New York Giants

Player	Anytime TD Probability
Cam Skattebo (RB)	56.6%
Jaxson Dart (QB)	27.2%
Wan'Dale Robinson (WR)	26.8%

New Orleans Saints

Player	Anytime TD Probability
Alvin Kamara (RB)	41.8%
Chris Olave (WR)	26.4%
Juwan Johnson (TE)	24.3%

Giants vs Saints player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Giants and Saints. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 5 games.

Giants vs. Saints quarterbacks

Of the starting quarterbacks, the Giants' Jaxson Dart is projected to throw for fewer yards than the Saints' Spencer Rattler.

Giants rushing

Cam Skattebo, Jaxson Dart and Devin Singletary are projected to be the leading rushers for the Giants.

Player	Position
Cam Skattebo	RB
Jaxson Dart	QB
Devin Singletary	RB

Saints rushing

Alvin Kamara, Kendre Miller and Spencer Rattler are expected to lead the Saints in rushing yards.

Player	Position
Alvin Kamara	RB
Kendre Miller	RB
Spencer Rattler	QB

Giants receiving

Wan'Dale Robinson, Darius Slayton, Theo Johnson, Cam Skattebo and Jalin Hyatt are projected to top the receiving yards for the Giants.

Player	Position
Wan'Dale Robinson	WR
Darius Slayton	WR
Theo Johnson	TE
Cam Skattebo	RB
Jalin Hyatt	WR

Saints receiving

Chris Olave, Rashid Shaheed, Juwan Johnson, Brandin Cooks and Alvin Kamara are projected to lead the Saints in receiving yards.

Player	Position
Chris Olave	WR
Rashid Shaheed	WR
Juwan Johnson	TE
Brandin Cooks	WR
Alvin Kamara	RB

Giants vs. Saints game-day updates and essential details

The NFL Week 5 game between the Saints and Giants at Caesars Superdome is scheduled to commence at 1:00PM ET.

• Who: New York Giants vs. New Orleans Saints
• Date: Sunday, October 5, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Caesars Superdome

Dimers' full preview of this week's Giants vs. Saints matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Saints picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Saints, with a 56% win probability, will likely beat the Giants in Week 5 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Saints insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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