MLS Betting Tips: Wednesday's Picks Include San Jose vs. LA Galaxy Play [5/28/2025]

Updated: May 28, 2025, 10:02 PM ET | First published: May 28, 2025, 12:10 AM ET

Written by Nick Slade, Chief Content Officer

Our team of MLS experts has found the best value bets for Wednesday.

MLS betting returns with another attractive slate on 5/28, and we're here to give you our top picks for Wednesday's soccer action.

Today's MLS best bets include matchups like the San Jose vs. LA Galaxy game at 10:15PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLS bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Wednesday, May 28, 2025, including our full set of MLS picks and best bets.

List of MLS Betting Tips Tonight [5/28, Updated 10:02PM ET]

After digging deep into the numbers and conducting thousands of simulations, our leading predictive analytics model has identified the best soccer bet for Wednesday, May 28, 2025.

This is the only free pick available right now. Our full set of MLS predictions is exclusive to Dimers Pro.

LA Galaxy ML (+110)

Probability: 50%
Edge: 2.4%
Matchup: San Jose vs. LA Galaxy (10:15PM ET, Wednesday)

Our model has pinpointed a high-probability MLS betting opportunity tonight, which comes in the San Jose vs. LA Galaxy matchup. We recommend a bet on the LA Galaxy ML at +110 odds, with our analysis showing a 50% chance of hitting and a compelling edge of 2.4%.

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Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for May 28, 2025.

List of Upcoming MLS Games to Bet On [5/28/2025]

San Jose vs. LA Galaxy (10:15PM ET, Wednesday)
Minnesota vs. Vancouver (10:30PM ET, Wednesday)
Colorado vs. Portland (10:30PM ET, Wednesday)

More About MLS

The best on this page form part of our MLS best bets series.

For more MLS betting content, we have MLS betting news and the latest MLS Cup odds and predictions.

Conclusion

Our MLS best bets are locked and loaded for May 28, 2025, featuring plays such as LA Galaxy ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLS insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

Written by

Nick Slade

Chief Content Officer

Nick Slade, with nearly two decades of experience, is the Chief Content Officer at Cipher Sports Technology Group, overseeing content for Dimers. He specializes in soccer, NBA, and NHL betting, leveraging predictive analytics and machine learning to provide accurate betting insights.

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