MLS betting tips: Sunday's picks highlight LA Galaxy vs. Portland play [3/22/2026]

Updated: Mar 22, 2026, 4:32 PM ET | First published: Mar 22, 2026, 2:03 AM ET

Written by Nick Slade, Chief Content Officer

Get MLS betting tips and picks for Sunday, March 22, 2026.

MLS Best Bets. — These MLS betting picks for March 22, 2026, are based on the latest odds and probabilities for Sunday's games.

Today’s MLS betting tips for March 22, 2026 are here, with LA Galaxy vs. Portland among the top plays identified by our model across Sunday’s MLS action.

Dimers’ predictive analytics engine runs 24/7, searching the latest soccer odds to find real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of MLS betting tips today [3/22, updated 4:32PM ET]

Below, you’ll find today’s best soccer bets, ranked by edge for Sunday, March 22, 2026.

Portland ML (+155)

Edge: 3.9%
Probability: 43.1%
Matchup: LA Galaxy vs. Portland (4:45PM ET, Sunday)

Our model has identified value on Portland to defeat LA Galaxy at +155 odds. A 43.1% probability produces an edge of 3.9%, making this the strongest play for today's MLS slate.

MLS best bets summary: Sunday, 3/22/2026

As of 4:32PM ET, here is our top MLS bet by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
LA Galaxy vs. Portland	Portland ML	+155 @ DraftKings	3.9%	43.1%

List of upcoming MLS games to bet on [3/22/2026]

LA Galaxy vs. Portland (4:45PM ET, Sunday)
Salt Lake vs. San Diego FC (7:00PM ET, Sunday)

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Ready to take your betting to the next level? See how Dimers Pro boosts our best bets by watching this explainer video.

Using Dimebot for betting research

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Conclusion

Our MLS best bets are locked and loaded for March 22, 2026, featuring plays such as Portland ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLS insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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Written by

Nick Slade

Chief Content Officer

Nick Slade, with nearly two decades of experience, is the Chief Content Officer at Cipher Sports Technology Group, overseeing content for Dimers. He specializes in soccer, NBA, and NHL betting, leveraging predictive analytics and machine learning to provide accurate betting insights.

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