Indianapolis Colts vs. Kansas City Chiefs: Experts release early Week 12 projections [2025]

The Indianapolis Colts and Kansas City Chiefs will meet in Week 12 of the NFL season at GEHA Field at Arrowhead Stadium on Sunday, November 23, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Chiefs as the most likely winner of this AFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Colts vs. Chiefs predictions page.

Indianapolis vs. Kansas City early predictions

Leveraging trusted machine learning and analysis, we have simulated the Colts vs. Chiefs game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Colts 38%, Chiefs 62%
• Predicted final score: Colts 23-26 Chiefs
• Spread: Colts (+3.5) 50%, Chiefs (-3.5) 50%
• Total points (49.5): Over 53%, Under 47%

As of November 17, 2025, these Colts-Chiefs numbers and predictions reflect the latest data and insights available.

Colts vs. Chiefs Week 12 details

The NFL Week 12 action between the Chiefs and Colts at GEHA Field at Arrowhead Stadium is scheduled for November 23, 2025.

• Who: Indianapolis Colts vs. Kansas City Chiefs
• Date: Sunday, November 23, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: GEHA Field at Arrowhead Stadium

Colts vs. Chiefs opening odds

We've researched the best betting odds across America for this Week 12 game, which are listed here:

• Spread: Colts +3.5 (-120), Chiefs -3.5 (-102)
• Moneyline: Colts +154, Chiefs -170
• Total: Over/Under 49.5 (-115/-105)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chiefs, with a 62% win probability, will likely beat the Colts in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Colts vs. Chiefs game, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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