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Pacers vs. Celtics prediction: Boston favored to win Monday's NBA game [12/22/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Indiana Pacers vs Boston Celtics predictions for NBA Monday.
The Boston Celtics and Indiana Pacers will meet in NBA action at TD Garden on Monday, starting at 7:30 PM ET.
Based on the latest simulation results and today’s injury news, Dimers' proven NBA model predicts the Celtics as the most likely winner of the Pacers vs. Celtics game.
This prediction follows the latest NBA Injury Report, which suggests the Celtics lineup will feature players like Jaylen Brown, Derrick White and Payton Pritchard, while the Pacers will be led by Pascal Siakam, Bennedict Mathurin and Andrew Nembhard.
This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Pacers vs. Celtics prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Monday's NBA game between the Pacers and Celtics 10,000 times as part of our NBA predictions coverage.
Our famous predictive model gives the Celtics a 78% chance of defeating the Pacers. Our predicted final score has the Celtics winning 116-107.
According to our model, the Pacers (+9.5) have a 53% chance of covering the spread, while the 225.5-point over/under has a 51% chance of staying under.
Pacers vs. Celtics odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | Pacers | Celtics |
|---|---|---|
| Spread | +9.5 (-102) | -9.5 (-118) |
| Moneyline | +370 | -470 |
| Total | o225.5 (-105) | u225.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Pacers vs. Celtics picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Pacers +9.5 | -102 |
| Moneyline | Pacers | +370 |
| Total | Over 225.5 | -105 |
According to our NBA best bets, the top play to make on this game is Pacers +9.5 at the spread.
Pacers vs. Celtics player props
NBA player props are a common way to wager on Monday's Pacers vs. Celtics matchup without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at TD Garden.
Pascal Siakam is expected to lead the Pacers with 22 points, 6 rebounds and 4 assists, while Jaylen Brown is projected to have 29 points, 7 rebounds and 5 assists for the Celtics.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
Pacers prediction
Our model's projected player stats for the Pacers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Pascal Siakam | 22 | 6 | 4 | 2 | 40 |
| B. Mathurin | 17 | 6 | 2 | 2 | 31 |
| Andrew Nembhard | 14 | 3 | 6 | 2 | 30 |
| Jay Huff | 10 | 5 | 1 | 2 | 24 |
| T.J. McConnell | 9 | 3 | 4 | 0 | 20 |
Celtics prediction
Projected points, rebounds, assists and three-pointers made for the Celtics:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jaylen Brown | 29 | 7 | 5 | 2 | 50 |
| Derrick White | 18 | 5 | 5 | 3 | 39 |
| P. Pritchard | 16 | 4 | 5 | 3 | 33 |
| Anfernee Simons | 14 | 3 | 3 | 2 | 24 |
| Neemias Queta | 11 | 9 | 2 | 0 | 28 |
Pacers vs. Celtics game-day updates and essential details
Monday's matchup between the Celtics and Pacers at TD Garden is scheduled to start at 7:30 PM ET.
- Who: Indiana Pacers vs. Boston Celtics
- Date: Monday, December 22, 2025
- Time: 7:30 PM ET/4:30PM PT
- Venue: TD Garden
Conclusion
We predict the Celtics, with a 78% win probability, will likely beat the Pacers on Monday, with Jaylen Brown projected for a game-high 50 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Pacers vs. Celtics insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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