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Pacers vs. Celtics prediction: Boston favored to win Monday's NBA game [12/22/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Indiana Pacers vs Boston Celtics predictions for NBA Monday.
The Boston Celtics will face the Indiana Pacers in NBA action at TD Garden on Monday, starting at 7:30 PM ET.
Based on updated simulations and today’s injury updates, Dimers' advanced NBA model predicts the Celtics as the most likely winner of the Pacers vs. Celtics game.
This prediction follows the latest NBA Injury Report, which suggests the Celtics lineup will feature stars like Jaylen Brown, Derrick White and Payton Pritchard, while the Pacers will be led by Pascal Siakam, Bennedict Mathurin and Andrew Nembhard.
This article offers a closer look at Monday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Pacers vs. Celtics prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the result of Monday's NBA matchup between the Pacers and Celtics 10,000 times as part of our NBA predictions coverage.
Our leading predictive model currently gives the Celtics an 81% chance of beating the Pacers. Our predicted final score has the Celtics winning 117-107.
According to our model, the Pacers (+11.5) have a 54% chance of covering the spread, while the over/under total of 225.5 points has an equal 50-50 chance of hitting.
Pacers vs. Celtics odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Pacers | Celtics |
|---|---|---|
| Spread | +11.5 (-106) | -11.5 (-110) |
| Moneyline | +450 | -590 |
| Total | o225.5 (-108) | u225.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Pacers vs. Celtics picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Pacers +11.5 | -106 |
| Moneyline | Pacers | +450 |
| Total | Under 225.5 | -108 |
According to our best NBA bets for Monday, the top play to make on this game is Pacers +11.5 at the spread.
Pacers vs. Celtics player props
NBA prop bets are an exciting way to wager on the Pacers vs. Celtics matchup without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at TD Garden.
Pascal Siakam is expected to lead the Pacers with 22 points, 6 rebounds and 4 assists, while Jaylen Brown is projected to have 28 points, 6 rebounds and 5 assists for the Celtics.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
Pacers prediction
Our model's projected player stats for the Pacers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Pascal Siakam | 22 | 6 | 4 | 2 | 40 |
| B. Mathurin | 17 | 6 | 2 | 2 | 31 |
| Andrew Nembhard | 14 | 3 | 6 | 2 | 31 |
| Jay Huff | 10 | 5 | 1 | 2 | 24 |
| Quenton Jackson | 9 | 3 | 3 | 1 | 20 |
Celtics prediction
Projected points, rebounds, assists and three-pointers made for the Celtics:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jaylen Brown | 28 | 6 | 5 | 2 | 48 |
| Derrick White | 17 | 5 | 5 | 3 | 38 |
| P. Pritchard | 16 | 5 | 4 | 3 | 33 |
| Anfernee Simons | 14 | 3 | 3 | 2 | 24 |
| Neemias Queta | 11 | 9 | 2 | 0 | 29 |
Pacers vs. Celtics game-day updates and essential details
Monday's action between the Celtics and Pacers at TD Garden is scheduled to commence at 7:30 PM ET.
- Who: Indiana Pacers vs. Boston Celtics
- Date: Monday, December 22, 2025
- Time: 7:30 PM ET/4:30PM PT
- Venue: TD Garden
Conclusion
We predict the Celtics, with an 81% win probability, will likely beat the Pacers on Monday, with Jaylen Brown projected for a game-high 48 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Pacers vs. Celtics insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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