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Cowboys vs. Panthers prediction: Why Dallas is favored to win in NFL Week 6, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Dallas Cowboys vs Carolina Panthers predictions for NFL Sunday.
NFL Week 6 action continues on Sunday at 1:00PM ET as the Dallas Cowboys square off with the Carolina Panthers at Bank of America Stadium.
Based on updated simulations, Dimers' proven NFL model predicts the Cowboys as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cowboys-Panthers game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Cowboys with a win probability of 61%, while the Panthers have 39%."
This gameday Cowboys vs. Panthers betting preview builds on my Cowboys vs. Panthers prediction that was released earlier in the week.
For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Cowboys vs. Panthers predictions page.
Cowboys vs. Panthers predictions
Since our Cowboys-Panthers predictions earlier in the week, we have simulated the result of Sunday's NFL game between the Cowboys and Panthers 10,000 times as part of our NFL predictions coverage.
Our independent predictive model currently gives the Cowboys a 61% chance of beating the Panthers in Week 6 of the NFL season. Our predicted final score has the Cowboys winning 24-21.
According to our model, the bookmakers have got it right, and the Cowboys and Panthers each have a 50% chance of covering the spread, while the over/under total of 47.5 points has a 56% chance of staying under.
To see win probabilities for every matchup this week, check out our expert NFL Week 6 straight up picks.
Cowboys vs. Panthers odds
We have researched the best NFL odds in America for this game, which are listed here:
| Bet Type | Cowboys | Panthers |
|---|---|---|
| Spread | -3 (+100) | +3 (-102) |
| Moneyline | -148 | +145 |
| Total | o47.5 (-105) | u47.5 (-115) |
All odds are correct at the time of publication and are subject to change.
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Cowboys vs. Panthers picks and best bets
Our model's biggest edge in today's Cowboys vs. Panthers matchup is on the spread.
Our expert predictions, aligned with the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Cowboys vs. Panthers TD scorers
Who will score the first touchdown in Cowboys vs. Panthers?
According to our list of touchdown scorer predictions for Week 6, Dallas' Javonte Williams is most likely to score the first touchdown in Cowboys vs. Panthers.
Our projections give Williams a 14.1% chance of scoring the first TD at Bank of America Stadium, while the Cowboys running back is a 55.1% chance of scoring an anytime touchdown.
First touchdown scorer predictions
Dallas Cowboys
| Player | First TD Probability |
|---|---|
| Javonte Williams (RB) | 14.1% |
| George Pickens (WR) | 9.8% |
| Jake Ferguson (TE) | 6.8% |
Carolina Panthers
| Player | First TD Probability |
|---|---|
| Rico Dowdle (RB) | 10.4% |
| Tetairoa McMillan (WR) | 7.7% |
| Xavier Legette (WR) | 4.4% |
Anytime touchdown scorer predictions
Dallas Cowboys
| Player | Anytime TD Probability |
|---|---|
| Javonte Williams (RB) | 55.1% |
| George Pickens (WR) | 42.8% |
| Jake Ferguson (TE) | 32.0% |
Carolina Panthers
| Player | Anytime TD Probability |
|---|---|
| Rico Dowdle (RB) | 44.7% |
| Tetairoa McMillan (WR) | 35.5% |
| Xavier Legette (WR) | 22.2% |
Cowboys vs Panthers player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cowboys and Panthers. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 6 games.
Cowboys vs. Panthers quarterbacks
Of the starting quarterbacks, the Cowboys' Dak Prescott is projected to throw for more yards than the Panthers' Bryce Young.
Cowboys rushing
Javonte Williams, Jaydon Blue and Dak Prescott are projected to be the leading rushers for the Cowboys.
| Player | Position |
|---|---|
| Javonte Williams | RB |
| Jaydon Blue | RB |
| Dak Prescott | QB |
Panthers rushing
Rico Dowdle, Trevor Etienne and Bryce Young are expected to lead the Panthers in rushing yards.
| Player | Position |
|---|---|
| Rico Dowdle | RB |
| Trevor Etienne | RB |
| Bryce Young | QB |
Cowboys receiving
George Pickens, Jake Ferguson, Ryan Flournoy, Jalen Tolbert and Javonte Williams are projected to top the receiving yards for the Cowboys.
| Player | Position |
|---|---|
| George Pickens | WR |
| Jake Ferguson | TE |
| Ryan Flournoy | WR |
| Jalen Tolbert | WR |
| Javonte Williams | RB |
Panthers receiving
Tetairoa McMillan, Xavier Legette, Tommy Tremble, Hunter Renfrow and Rico Dowdle are projected to lead the Panthers in receiving yards.
| Player | Position |
|---|---|
| Tetairoa McMillan | WR |
| Xavier Legette | WR |
| Tommy Tremble | TE |
| Hunter Renfrow | WR |
| Rico Dowdle | RB |
Cowboys vs. Panthers game-day updates and essential details
The NFL Week 6 matchup between the Panthers and Cowboys at Bank of America Stadium is scheduled to commence at 1:00PM ET.
- Who: Dallas Cowboys vs. Carolina Panthers
- Date: Sunday, October 12, 2025
- Time: 1:00PM ET/10:00AM PT
- Venue: Bank of America Stadium
Dimers' full preview of Sunday's Cowboys vs. Panthers matchup includes our prediction, picks and the latest betting odds.
Before making any Cowboys vs. Panthers picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Cowboys, with a 61% win probability, will likely beat the Panthers in Week 6 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Cowboys vs. Panthers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NFL
Keep up with the latest NFL betting news and NFL parlay picks throughout the season. Plus, our Super Bowl odds offer the latest projections for the Super Bowl, AFC, NFC and each division.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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