College football picks today: Week 18 Tuesday best bets include New Orleans Bowl play [12/23/2025]

Today’s college football picks for December 23, 2025 are here, with Western Kentucky vs. Southern Miss and UNLV vs. Ohio among the top plays identified by our model across Tuesday’s college football schedule.

Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to unearth legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of college football picks today [12/23, updated 1:31PM ET]

Below, you’ll find today’s best college football bets, ranked by edge for Tuesday, December 23, 2025.

Western Kentucky vs. Southern Miss over 58.5 points (-115)

• Edge: 6.4%
• Probability: 59.8%
• Matchup: New Orleans Bowl (5:30PM ET, Tuesday)

Our model has identified value on over 58.5 points in Western Kentucky vs. Southern Miss at -115 odds. A 59.8% probability produces an edge of 6.4%, making this the strongest play for today's college football slate.

Ohio ML (+220)

• Edge: 5.4%
• Probability: 36.6%
• Matchup: Frisco Bowl (9:00PM ET, Tuesday)

Ohio ML carries a 5.4% edge and a probability of 36.6% at +220 odds, according to our model.

Toledo +12.5 (-108)

• Edge: 4.8%
• Probability: 56.7%
• Matchup: Boca Raton Bowl (2:00PM ET, Tuesday)

Toledo +12.5 vs. Louisville at -108 odds shows a 4.8% edge, supported by a 56.7% probability in simulations.

Toledo ML (+390)

• Edge: 3.6%
• Probability: 24%
• Matchup: Boca Raton Bowl (2:00PM ET, Tuesday)

A 3.6% edge and 24% probability make Toledo at the moneyline at a value play in the Toledo vs. Louisville matchup, per our model.

Toledo vs. Louisville under 44.5 points (-105)

• Edge: 2.2%
• Probability: 53.4%
• Matchup: Boca Raton Bowl (2:00PM ET, Tuesday)

Toledo vs. Louisville under 44.5 points at -105 odds presents a 2.2% edge, with simulations resulting in a probability of 53.4%.

NCAAF best bets summary: Tuesday, 12/23/2025

As of 1:31PM ET, here are our top college football bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Western Kentucky vs. Southern Miss	Over 58.5 Points	-115 @ BetMGM	6.4%	59.8%
UNLV vs. Ohio	Ohio ML	+220 @ BetMGM	5.4%	36.6%
Toledo vs. Louisville	Toledo +12.5	-108 @ DraftKings	4.8%	56.7%
Toledo vs. Louisville	Toledo ML	+390 @ FanDuel	3.6%	24%
Toledo vs. Louisville	Under 44.5 Points	-105 @ FanDuel	2.2%	53.4%

List of upcoming college football games to bet on now

• Toledo vs. Louisville (2:00PM ET, Tuesday)
• Western Kentucky vs. Southern Miss (5:30PM ET, Tuesday)
• UNLV vs. Ohio (9:00PM ET, Tuesday)

More college football betting

For further insights into this week's NCAAF action, check out the latest from the Dimers Sports Betting Podcast:

Conclusion

Our college football best bets are locked and loaded for December 23, 2025, featuring plays such as over 58.5 points in the Western Kentucky vs. Southern Miss matchup and Ohio ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.