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College football picks today: Week 18 Tuesday best bets include New Orleans Bowl play [12/23/2025]
Get college football picks and best bets for Tuesday, December 23, 2025.

Today’s college football picks for December 23, 2025 are here, with Western Kentucky vs. Southern Miss and UNLV vs. Ohio among the top plays identified by our model across Tuesday’s college football action.
Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to unearth legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of college football picks today [12/23, updated 3:35AM ET]
Below, you’ll find today’s best college football bets, ranked by edge for Tuesday, December 23, 2025.
Western Kentucky vs. Southern Miss over 58.5 points (-115)
- Edge: 6.4%
- Probability: 59.8%
- Matchup: New Orleans Bowl (5:30PM ET, Tuesday)
Our model has identified value on over 58.5 points in Western Kentucky vs. Southern Miss at -115 odds. A 59.8% probability produces an edge of 6.4%, making this the strongest play for today's college football slate.
Ohio ML (+220)
- Edge: 5.6%
- Probability: 36.8%
- Matchup: Frisco Bowl (9:00PM ET, Tuesday)
Ohio ML carries a 5.6% edge and a probability of 36.8% at +220 odds, according to our model.
Toledo vs. Louisville over 43.5 points (-108)
- Edge: 3.8%
- Probability: 55.7%
- Matchup: Boca Raton Bowl (2:00PM ET, Tuesday)
Toledo vs. Louisville over 43.5 points at -108 odds shows a 3.8% edge, supported by a 55.7% probability in simulations.
Southern Miss ML (+100)
- Edge: 2.7%
- Probability: 52.7%
- Matchup: New Orleans Bowl (5:30PM ET, Tuesday)
A 2.7% edge and 52.7% probability make Southern Miss at the moneyline at a value play in the Western Kentucky vs. Southern Miss matchup, per our model.
NCAAF best bets summary: Tuesday, 12/23/2025
As of 3:35AM ET, here are our top college football bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Western Kentucky vs. Southern Miss | Over 58.5 Points | -115 @ DraftKings | 6.4% | 59.8% |
| UNLV vs. Ohio | Ohio ML | +220 @ BetMGM | 5.6% | 36.8% |
| Toledo vs. Louisville | Over 43.5 Points | -108 @ DraftKings | 3.8% | 55.7% |
| Western Kentucky vs. Southern Miss | Southern Miss ML | +100 @ BetMGM | 2.7% | 52.7% |
List of upcoming college football games to bet on now
- Toledo vs. Louisville (2:00PM ET, Tuesday)
- Western Kentucky vs. Southern Miss (5:30PM ET, Tuesday)
- UNLV vs. Ohio (9:00PM ET, Tuesday)
Using Dimebot for betting research
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Conclusion
Our college football best bets are locked and loaded for December 23, 2025, featuring plays such as over 58.5 points in the Western Kentucky vs. Southern Miss matchup and Ohio ML. Powered by advanced simulations, these picks are here to boost your betting game.
This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
All odds and probabilities in this article are correct and accurate at the time of publication.
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