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Astros vs. Cubs Prediction, Picks and Odds
Our detailed prediction and analysis for the Astros vs. Cubs MLB game on May 22, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
FINAL
MLB
Astros
Spencer Arrighetti 5-1, 1.50 ERA
4
2
May 22, 2:20 PM ET Wrigley Field
Cubs
Jameson Taillon 2-3, 4.97 ERA
May 22, 2:20 PM ET Wrigley Field
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | R | H | E | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Astros | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 4 | 9 | 2 |
Cubs | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 4 | 0 |
Live Probabilities
Moneyline
Over / Under
Run Line
- Astros
- Cubs
Win Probability
Last At Bat
Outs
Ian Happ pops out to shallow right field to Christian Walker.
Quick Box Score
Hitting
Pitching
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | J. Peña | SS | 5 | 0 | 1 | 0 | 0 | 0 | 1 | .200 | 0.400 |
| 2 | I. Paredes | 3B | 4 | 1 | 1 | 0 | 0 | 1 | 0 | .250 | 0.650 |
| 3 | Y. Alvarez | DH | 3 | 0 | 1 | 0 | 0 | 2 | 1 | .333 | 0.933 |
| 4 | C. Walker | 1B | 5 | 1 | 1 | 0 | 0 | 0 | 3 | .200 | 0.400 |
| 5 | J. Meyers | CF | 4 | 0 | 1 | 0 | 0 | 0 | 1 | .250 | 0.500 |
| 6 | N. Allen | 2B | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
| 7 | C. Smith | RF | 4 | 0 | 1 | 0 | 0 | 0 | 1 | .250 | 0.500 |
| 8 | Z. Cole | LF | 4 | 0 | 0 | 1 | 0 | 0 | 1 | .000 | 0.000 |
| 9 | C. Vázquez | C | 4 | 1 | 2 | 2 | 1 | 0 | 1 | .500 | 1.750 |
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | N. Hoerner | 2B | 4 | 0 | 0 | 0 | 0 | 1 | 1 | .000 | 0.200 |
| 2 | M. Busch | 1B | 3 | 0 | 0 | 0 | 0 | 1 | 0 | .000 | 0.400 |
| 3 | A. Bregman | 3B | 3 | 0 | 1 | 0 | 0 | 1 | 0 | .333 | 0.933 |
| 4 | I. Happ | LF | 5 | 0 | 1 | 0 | 0 | 0 | 2 | .200 | 0.600 |
| 5 | S. Suzuki | RF | 4 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
| 6 | M. Ballesteros | DH | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
| 7 | C. Kelly | C | 3 | 0 | 0 | 0 | 0 | 0 | 1 | .000 | 0.250 |
| 8 | P. Crow-Armstrong | CF | 2 | 1 | 1 | 2 | 1 | 2 | 0 | .500 | 2.750 |
| 9 | D. Swanson | SS | 4 | 0 | 0 | 0 | 0 | 0 | 1 | .000 | 0.000 |
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Astros vs. Cubs: Detailed Breakdown
Matchup Overview
- Teams: Astros vs. Cubs
- Date: Friday, May 22, 2026
- Time: 2:20 PM ET
- Venue: Wrigley Field
Current Betting Odds
- Spread: Cubs favored at -1.5
- Total (Over/Under): 6.5
- Moneyline Odds: Astros +135, Cubs -135
Dimers' Win Probabilities
- Astros: 43%
- Cubs: 57%
Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.
Our Prediction: Who Wins?
After extensive simulations, our model gives the Astros a win probability of 43%, while the Cubs have a win probability of 57%. Discover the best spread, over/under, and moneyline odds for the game on this page.
Summary
According to our analysis, the Cubs are more likely to beat the Astros in the MLB game at Wrigley Field on Friday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.
Our Astros vs. Cubs predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.