Cardinals vs. Pirates: MLB Prediction & Analysis

Our detailed prediction and analysis for the Cardinals vs. Pirates MLB game on Thursday, September 24, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
FINAL
MLB sport icon
MLB
Cardinals
Kyle Leahy 10-5, 3.65 ERA
1
2
PNC Park
Pirates
Paul Skenes 10-11, 3.91 ERA
PNC Park
1 2 3 4 5 6 7 8 9 RHE
Cardinals
1 0 0 0 0 0 0 0 0 1 5 2
Pirates
1 0 0 0 0 0 0 1 X 2 7 0
Live Probabilities
Win %
  • Cardinals
    0%
  • Pirates
    100%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Thomas Saggese strikes out swinging.
Quick Box Score
Cardinals Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Wetherholt 2B4020000.5001.250
2 I. Herrera C4010002.2500.500
3 A. Burleson 1B4111101.2501.250
4 J. Walker RF3000012.0000.250
5 L. Bernal DH4000003.0000.000
6 J. Fermín PH1000001.0000.000
7 T. Saggese 3B3000002.0000.250
8 N. Church CF3010000.3330.666
9 M. Winn SS3000002.0000.000
Pirates Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 O. Cruz CF4120000.5001.250
2 K. Griffin SS4020001.5001.000
3 B. Lowe 2B3011012.3330.833
4 R. O'Hearn DH3000011.0000.250
5 J. Triolo 3B0000000.0000.000
6 B. Cook RF0000000.0000.000
7 S. Horwitz 1B3001000.0000.000
8 B. Reynolds LF0000010.0001.000
9 H. Davis C4000002.0000.000

Cardinals vs. Pirates: Detailed Breakdown

Matchup overview: MLB Thursday

  • Teams: St. Louis Cardinals vs. Pittsburgh Pirates
  • Date: Thursday, September 24, 2026
  • Time: 12:35PM ET
  • Venue: PNC Park

Current betting odds

  • Spread: Cardinals (+1.5, -156), Pirates (-1.5, +156)
  • Moneyline: Cardinals +147, Pirates -150
  • Total (Over/Under): 6.5 runs (-120/+127)

Dimers’ win probabilities

  • Cardinals: 39.8%
  • Pirates: 60.2%

Dimers' predictive MLB model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Cardinals a win probability of 39.8%, while the Pirates have a win probability of 60.2%.

Summary

According to our analysis, the Pirates are more likely to beat the Cardinals in the MLB game at PNC Park on Thursday. Discover the best run line, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Cardinals vs. Pirates predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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