Cardinals vs. Pirates: MLB Prediction & Analysis

Our detailed prediction and analysis for the Cardinals vs. Pirates MLB game on Thursday, September 24, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
MLB
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MLB
Cardinals
Kyle Leahy 10-5, 3.65 ERA
vs.
PNC Park
Pirates
Paul Skenes 10-11, 3.91 ERA
PNC Park
Pre-Game Probabilities Last Update:

Moneyline

Moneyline
Win %
  • Cardinals
    39.9%
    NovigNovig
  • Pirates
    60.1%
    NovigNovig

Cardinals vs. Pirates: Detailed Breakdown

Matchup overview: MLB Thursday

  • Teams: St. Louis Cardinals vs. Pittsburgh Pirates
  • Date: Thursday, September 24, 2026
  • Time: 12:35PM ET
  • Venue: PNC Park

Current betting odds

  • Spread: Cardinals (+1.5, -163), Pirates (-1.5, +160)
  • Moneyline: Cardinals +144, Pirates -150
  • Total (Over/Under): 7 runs (+100/-115)

Dimers’ win probabilities

  • Cardinals: 40.3%
  • Pirates: 59.7%

Dimers' predictive MLB model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Cardinals a win probability of 40.3%, while the Pirates have a win probability of 59.7%.

Summary

According to our analysis, the Pirates are more likely to beat the Cardinals in the MLB game at PNC Park on Thursday. Discover the best run line, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Cardinals vs. Pirates predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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